Find coaches from Knoxville, TN to Tupelo

Find affordable coach tickets from Knoxville, TN to Tupelo with flexible options. Book your journey now

Join 75M+ travellers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every stage.
Cancel anytime and receive a 100% refund, no reason needed.
Today23 Jun
Tomorrow24 Jun
Wed25 Jun
from US$108
Thu26 Jun
Fri27 Jun
from US$106
Sat28 Jun
Sun29 Jun
Mon30 Jun

Cheap buses leaving Wednesday

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: 25 June at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: 26 June at
    Destination city: Tupelo
    Destination location: Tupelo (Brothers Quick Stop)
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Knoxville to Tupelo: Trip Overview

Average ticket priceUS$110
Average bus trip duration11h 5m
Number of daily buses1
Earliest bus departure19:20
Distance297 miles
Latest bus departure19:25

Knoxville to Tupelo Bus

Busbud helps you find a bus from Knoxville to Tupelo. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Knoxville to Tupelo.

Discover how much the bus trip from Knoxville to Tupelo will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Knoxville, TN - Tupelo

  1. What's the distance between Knoxville and Tupelo by coach?

    The journey from Knoxville to Tupelo by coach covers an approximate distance of 294 miles (473 km).

  2. How can I travel from Knoxville to Tupelo avoiding air travel?

    To travel from Knoxville to Tupelo without flying, you can take the coaches. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You also have the option of utilising carpooling services.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
21/06
No data
22/06
No data
Today
No data
24/06
No data
25/06
US$100
26/06
No data
27/06
US$98
28/06
No data
busbud logoThe cheapest trip from Knoxville to Tupelo was searched and found on 27 Jun 2025 with a price of US$98

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville to Tupelo as early as possible.

You can expect to pay from US$98 to US$100 for a bus ticket from Knoxville to Tupelo based on the last 2 days. You can expect to find the cheapest price for the trip at US$98, which is on 2025-06-27.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Knoxville and Tupelo!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Knoxville to Tupelo.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Knoxville to Tupelo will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Knoxville to Tupelo.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

Will you be returning to Knoxville by bus?

Bus from Knoxville to Tupelo

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Buses Connecting Knoxville

Buses Leaving from Knoxville

Buses Going to Knoxville

Popular Buses Connecting Tupelo

Buses Leaving from Tupelo

Buses Going to Tupelo