Find coaches from Tupelo to Chicago

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Next departures

Next departures from Tupelo to Chicago on 18 September
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc. + FlixBus
Tupelo (Brothers Quick Stop)
Chicago 95Th & Dan RyanCheapest
Greyhound Lines, Inc. + FlixBus
Tupelo (Brothers Quick Stop)
Chicago 95Th & Dan RyanFastest
Greyhound Lines, Inc. + FlixBus
Tupelo (Brothers Quick Stop)
Downtown Greyhound StationNo tags
Greyhound Lines, Inc.
Tupelo (Brothers Quick Stop)
Downtown Greyhound StationNo tags
Greyhound Lines, Inc. + FlixBus
Tupelo (Brothers Quick Stop)
Downtown Greyhound StationNo tags

Accepted payments

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Bus Tupelo to Chicago: Trip Overview

Average ticket priceUS$123
Average bus trip duration22h 45m
Number of daily buses10
Earliest bus departure05:35
Distance530 miles
Latest bus departure23:15

Tupelo to Chicago Bus

With Busbud, comparing and booking tickets for a bus from Tupelo to Chicago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Tupelo to Chicago from the most reliable bus companies operating this trip.

Discover how much the bus trip from Tupelo to Chicago will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Tupelo - Chicago

  1. What's the distance between Tupelo and Chicago by coach?

    The distance between Tupelo and Chicago by coach is approximately 529 miles (853 km).

  2. How can I travel from Tupelo to Chicago avoiding air travel?

    You can choose the coach to travel this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You also have the option of utilising carpooling services.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
12/09
US$84
13/09
No data
Today
US$158
15/09
No data
16/09
No data
17/09
No data
18/09
US$122
19/09
US$103
busbud logoThe cheapest trip from Tupelo to Chicago was searched and found on 12 Sept 2025 with a price of US$84

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to Chicago as early as possible.

You can expect to pay from US$84 to US$286 for a bus ticket from Tupelo to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$103, which is on 2025-09-19.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Tupelo to Chicago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Tupelo to Chicago, get comfy and count the stars.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Tupelo to Chicago will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Tupelo to Chicago.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to Tupelo by bus?

Bus from Chicago to Tupelo

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