Find coaches from Tupelo to Chicago

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Today3 Jun
Tomorrow4 Jun
Thu5 Jun
Fri6 Jun
from US$95
Sat7 Jun
Sun8 Jun
Mon9 Jun
Tue10 Jun

Cheap buses leaving Friday

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 6 June at
    Departure city: Tupelo
    Departure location: Tupelo (Brothers Quick Stop)
    Arrival time: 7 June at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 6 June at
    Departure city: Tupelo
    Departure location: Tupelo (Brothers Quick Stop)
    Arrival time: 6 June at
    Destination city: Chicago
    Destination location: Chicago 95Th & Dan Ryan
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: 6 June at
    Departure city: Tupelo
    Departure location: Tupelo (Brothers Quick Stop)
    Arrival time: 6 June at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: 6 June at
    Departure city: Tupelo
    Departure location: Tupelo (Brothers Quick Stop)
    Arrival time: 7 June at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 6 June at
    Departure city: Tupelo
    Departure location: Tupelo (Brothers Quick Stop)
    Arrival time: 8 June at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:

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Bus Tupelo to Chicago: Trip Overview

Average ticket priceUS$140
Average bus trip duration1d
Number of daily buses10
Earliest bus departure05:35
Distance520 miles
Latest bus departure23:15

Tupelo to Chicago Bus

With Busbud, comparing and booking tickets for a bus from Tupelo to Chicago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Tupelo to Chicago from the most reliable bus companies operating this trip.

Discover how much the bus trip from Tupelo to Chicago will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Tupelo - Chicago

  1. How much does it cost to travel by coach from Tupelo to Chicago?

    For coach travel from Tupelo to Chicago, ticket prices typically start at US$78 and can reach a maximum of US$302. These prices can change depending on factors like the date, the class and the coach company you choose. To get accurate and up-to-date pricing information, check out all your options on our search tool.

  2. How long is a coach from Tupelo to Chicago?

    The average duration for a trip from Tupelo to Chicago by coach is around 1d. The fastest coach journey typically takes 16h 15m. However, please keep in mind that your specific travel time may vary due to the prevailing traffic conditions along the route.

  3. At what time does the first coach from Tupelo to Chicago leave?

    The first coach to Chicago from Tupelo departs at 05:35. Keep in mind that departure times might change on weekends and holidays.

  4. What's the distance between Tupelo and Chicago by coach?

    The distance between Tupelo and Chicago by coach is approximately 529 miles (853 km).

  5. How can I travel from Tupelo to Chicago avoiding air travel?

    You can choose the coach to travel this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You also have the option of utilising carpooling services.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
01/06
No data
02/06
US$185
Today
US$75
04/06
No data
05/06
US$114
06/06
US$115
07/06
No data
08/06
No data
busbud logoThe cheapest trip from Tupelo to Chicago was searched and found on 3 Jun 2025 with a price of US$75

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to Chicago as early as possible.

You can expect to pay from US$75 to US$219 for a bus ticket from Tupelo to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$114, which is on 2025-06-05.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Tupelo to Chicago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Tupelo to Chicago, get comfy and count the stars.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Tupelo to Chicago will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Tupelo to Chicago.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to Tupelo by bus?

Bus from Tupelo to Chicago

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