Bus Tickets from Knoxville, TN to Tupelo

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TodayJun 23
TomorrowJun 24
WedJun 25
from US$108
ThuJun 26
FriJun 27
from US$106
SatJun 28
SunJun 29
MonJun 30

Cheap buses leaving Wednesday

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: June 25 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: June 26 at
    Destination city: Tupelo
    Destination location: Tupelo (Brothers Quick Stop)
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

Last refresh of the prices: Last Wednesday at 11:48 AM EDT.

Prices and availability are subject to change.

Accepted payments

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Bus Knoxville to Tupelo: Trip Overview

Average Ticket PriceUS$110
Average Bus Trip Duration11h 5m
Number of daily buses1
Earliest bus departure7:20pm
Distance479 km
Latest bus departure7:25pm

Knoxville to Tupelo Bus

Busbud helps you find a bus from Knoxville to Tupelo. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Knoxville to Tupelo.

Discover how much the bus trip from Knoxville to Tupelo will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Knoxville, TN - Tupelo

  1. How far is Knoxville from Tupelo?

    Knoxville and Tupelo are 473 km (294 miles) apart.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06-21
No data
06-22
No data
Today
No data
06-24
No data
06-25
US$100
06-26
No data
06-27
US$98
06-28
No data
busbud logoThe cheapest trip from Knoxville to Tupelo was searched and found on Jun 27, 2025 with a price of US$98

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville to Tupelo, as early as possible.

You can expect to pay from US$98 to US$100 for a bus ticket from Knoxville to Tupelo based on the last 2 days. You can expect to find the cheapest price for the trip at US$98 which is on 2025-06-27.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Knoxville and Tupelo!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Knoxville to Tupelo.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Knoxville to Tupelo will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Knoxville to Tupelo.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

Will you be returning to Knoxville by bus?

Bus from Knoxville to Tupelo

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