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- This trip is recommended because it is the: Cheapest + FastestDeparture time: June 21 atDeparture city: KnoxvilleDeparture location: Knoxville Bus StationArrival time: June 22 atDestination city: DurhamDestination location: Durham Greyhound Bus StationOperated by: Greyhound Lines, Inc.
Vehicle: BusDuration:
Last refresh of the prices: Last Saturday at 9:51 PM EDT.
Prices and availability are subject to change.
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Bus Knoxville to Durham: Trip Overview
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Knoxville to Durham Bus
Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Knoxville to Durham.
We make sure you can find a bus service from Knoxville to Durham from the most reliable bus companies operating this trip.
From cheap bus tickets to more luxurious buses travelling from Knoxville to Durham, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in Knoxville and Durham?
Frequently asked questions on the trip Knoxville, TN - Durham, NC, US
What is the distance between Knoxville and Durham?
It's about 453 km (281 miles) from Knoxville to Durham.
What are the departure and arrival locations for buses traveling from Knoxville to Durham?
Buses traveling this route start their trip at 100 Kirkwood St, in Knoxville, and end it at Durham Greyhound Bus Station, in Durham.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville to Durham was searched and found on Jun 20, 2025 with a price of US$73To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville to Durham, as early as possible.
You can expect to pay from US$73 to US$113 for a bus ticket from Knoxville to Durham based on the last 2 days. You can expect to find the cheapest price for the trip at US$85 which is on 2025-06-23.
About Bus Travel
Bus Travel Tips
If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Knoxville to Durham but it'll also be endearing to native speakers who will surely appreciate your effort.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Knoxville to Durham, get comfy and count the stars.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Knoxville to Durham that are otherwise impossible to come by with a plane.
Tune out to the fine sounds of your best music playlist on your bus trip from Knoxville to Durham while indulging in miles on end of beautiful scenic views.
Did you know?
The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!
Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.
Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!
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