Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Knoxville Bus Station | Chicago 95Th & Dan Ryan | Cheapest | |||||
 | Knoxville Bus Station | 537-517 W. Jackson Blvd | Fastest | |||||
| Knoxville Bus Station | Downtown Greyhound Station | No tags | |||||
Greyhound Lines, Inc. + FlixBus | Knoxville Bus Station | Downtown Greyhound Station | No tags | |||||
| Knoxville Bus Station | 537-517 W. Jackson Blvd | No tags |
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Bus Knoxville, TN to Chicago: Trip Overview
Compare bus companies
Based on 87228 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at US$108
Greyhound Knoxville Chicago recent customer reviews
the bus was supposed to leave Knoxville at 7:10 pm but left at 10:00 pm. We didn't know when the bus would leave, we got a lot of stress. In addition, there is no bus station building in Knoxville and we were on the street all this time. Since the bus left late, I missed my bus from Nashville to Chicago. and instead of arriving in Chicago at 8:35 am, I arrived at 1:00 pm. I wrote to the support service, I wanted to return the ticket due to the bus being late and fly by plane, but they answered me with automatic messages. the bus was supposed to leave Knoxville at 7:10 pm but left at 10:00 pm. We didn't know when the bus would leave, we got a lot of stress. In addition, there is no bus station building in Knoxville and we were on the street all this time. Since the bus left late, I missed my bus from Nashville to Chicago. and instead of arriving in Chicago at 8:35 am, I arrived at 1:00 pm. and I also didn’t like that they woke me up and kicked me off the bus at every stop
Artur T.
We were waylaid for an incredible 7 hours between Knoxville and Nashville because of an extremely suspect technical issue regarding the brightness of headlights. During this time a customer, understandably dissatisfied with the ride and the information given to them, expressed this to the driver whereupon the driver called the police on the passenger who was escorted off the bus by cops. Following our arrival into Knoxville we were again delayed when, due to understaffing, we were unable to get our redirected tickets in time. The actual ticketing staff at the Nashville terminal is the only reason the employees get 2 stars. He deserves a raise and probably a better job. Finally, after everything was sorted and we made our way into Chicago, our luggage went untransfered in Indianapolis and we had to return to get it the next day. This was a nightmarish ordeal and I will, from here on out, be spending my money on alternative methods of transportation.
Willem D.
It took us to get to home 24hrs instead 12 hrs with additional cost of $230 due to delay and no bus available at connections.
Nareshkumar P.
Knoxville to Chicago Bus
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Frequently asked questions on the trip Knoxville, TN - Chicago
What is the distance between Knoxville and Chicago?
The distance covered from Knoxville to Chicago is 731 km (454 miles).
What are the departure and arrival locations for buses traveling from Knoxville to Chicago?
Buses traveling this route start their trip at 100 Kirkwood St, in Knoxville, and end it at Downtown Greyhound Station, in Chicago.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Chicago was searched and found on Sep 3, 2025 with a price of US$101To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Chicago, as early as possible.
You can expect to pay from US$101 to US$169 for a bus ticket from Knoxville, TN to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$101 which is on 2025-09-03.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while travelling from Knoxville to Chicago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Knoxville to Chicago, get comfy and count the stars.
Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Knoxville to Chicago will emit less CO2 than a car or an airplane.
Tune out to the fine sounds of your best music playlist on your bus trip from Knoxville to Chicago while indulging in miles on end of beautiful scenic views.
Did you know?
The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
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Popular Buses Connecting Knoxville
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Buses Going to Knoxville
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Popular routes in this country
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