Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Pittsburgh Intermodal Station | Knoxville Bus Station | Cheapest | |||||
| Pittsburgh Intermodal Station | Knoxville Bus Station | Fastest |
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Bus Pittsburgh to Knoxville, TN: Trip Overview
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Based on 87264 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at US$69
Pittsburgh to Knoxville Bus
With Busbud, comparing and booking tickets for a bus from Pittsburgh to Knoxville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
Bus service from Pittsburgh to Knoxville will be provided by the most trusted bus companies.
From cheap bus tickets to more luxurious buses travelling from Pittsburgh to Knoxville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in Pittsburgh and Knoxville?
Frequently asked questions on the trip Pittsburgh - Knoxville, TN
What is the distance between Pittsburgh and Knoxville?
The distance covered from Pittsburgh to Knoxville is 606 km (376 miles).
What are the departure and arrival locations for buses traveling from Pittsburgh to Knoxville?
Buses traveling this route start their trip at Intermodal Station, in Pittsburgh, and end it at 100 Kirkwood St, in Knoxville.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Pittsburgh to Knoxville, TN was searched and found on Sep 23, 2025 with a price of US$62To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Pittsburgh to Knoxville, TN, as early as possible.
You can expect to pay from US$62 to US$135 for a bus ticket from Pittsburgh to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at US$62 which is on 2025-09-23.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while travelling from Pittsburgh to Knoxville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Much more than a mere vehicle taking you from Pittsburgh to Knoxville, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Pittsburgh to Knoxville that are otherwise impossible to come by with a plane.
Make a music playlist for your bus ride from Pittsburgh to Knoxville, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.
Top travelled bus routes
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