Bus Tickets from Chicago to Tupelo

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TomorrowJun 6
SatJun 7
from US$102
SunJun 8
from US$113
MonJun 9
TueJun 10
WedJun 11
ThuJun 12
FriJun 13

Cheap buses leaving Saturday

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: June 7 at
    Departure city: Chicago
    Departure location: Chicago 95Th & Dan Ryan
    Arrival time: June 8 at
    Destination city: Tupelo
    Destination location: Tupelo (Brothers Quick Stop)
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: June 7 at
    Departure city: Chicago
    Departure location: Downtown Greyhound Station
    Arrival time: June 8 at
    Destination city: Tupelo
    Destination location: Tupelo (Brothers Quick Stop)
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 7 at
    Departure city: Chicago
    Departure location: Downtown Greyhound Station
    Arrival time: June 8 at
    Destination city: Tupelo
    Destination location: Tupelo (Brothers Quick Stop)
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 7 at
    Departure city: Chicago
    Departure location: Downtown Greyhound Station
    Arrival time: June 8 at
    Destination city: Tupelo
    Destination location: Tupelo (Brothers Quick Stop)
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 7 at
    Departure city: Chicago
    Departure location: 537-517 W. Jackson Blvd
    Arrival time: June 8 at
    Destination city: Tupelo
    Destination location: Tupelo (Brothers Quick Stop)
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

Last refresh of the prices: Last Sunday at 6:02 PM CDT.

Prices and availability are subject to change.

Accepted payments

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Bus Chicago to Tupelo: Trip Overview

Average Ticket PriceUS$141
Average Bus Trip Duration22h 55m
Number of daily buses4
Earliest bus departure12:30am
Distance854 km
Latest bus departure10:30pm

Chicago to Tupelo Bus

With Busbud, comparing and booking tickets for a bus from Chicago to Tupelo is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Chicago to Tupelo.

Discover how much the bus trip from Chicago to Tupelo will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Chicago - Tupelo

  1. How long is the bus trip from Chicago to Tupelo?

    The bus ride from Chicago to Tupelo takes 22h 55m, on average. The fastest bus on this trip will get to Tupelo in 12h 10m

  2. How far is Chicago from Tupelo?

    The distance covered from Chicago to Tupelo is 853 km (529 miles).

  3. What is the cheapest way to go from Chicago to Tupelo?

    Taking the bus is the cheapest option to travel from Chicago to Tupelo. The ticket price for this bus starts at US$73, making this your best choice for this trip.

  4. How much does it cost to take the bus from Chicago to Tupelo?

    The bus fare from Chicago to Tupelo is approximately US$141.

  5. Can I take an overnight bus from Chicago to Tupelo?

    Yes! Catch buses leaving from Chicago until 10:30pm and reaching Tupelo on the following day.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06-03
No data
06-04
US$132
Today
US$115
06-06
No data
06-07
US$95
06-08
US$106
06-09
US$93
06-10
US$94
busbud logoThe cheapest trip from Chicago to Tupelo was searched and found on Jun 9, 2025 with a price of US$93

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Tupelo, as early as possible.

You can expect to pay from US$93 to US$198 for a bus ticket from Chicago to Tupelo based on the last 2 days. You can expect to find the cheapest price for the trip at US$93 which is on 2025-06-09.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Chicago to Tupelo.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Chicago to Tupelo.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Chicago to Tupelo will emit less CO2 than a car or an airplane.

Tune out to the fine sounds of your best music playlist on your bus trip from Chicago to Tupelo while indulging in miles on end of beautiful scenic views.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Chicago by bus?

Bus from Chicago to Tupelo

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