Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Detroit Bus Station | Knoxville Bus Station | CheapestFastest | |||||
| Detroit Bus Station | Knoxville Bus Station | No tags | |||||
| Detroit Bus Station | Knoxville Bus Station | No tags | |||||
| Detroit Bus Station | Knoxville Bus Station | No tags |
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Bus Detroit, MI to Knoxville, TN: Trip Overview
Compare bus companies
Based on 87230 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at US$65
Greyhound Detroit Knoxville recent customer reviews
Very late arrival
Ronell W.
The drivers were awesome. Trip was very comfortable.
Juliana T.
Detroit to Knoxville Bus
Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Detroit to Knoxville.
We make it our job to connect you with the most dependable bus companies that cover bus service from Detroit to Knoxville.
From cheap bus tickets to more luxurious buses travelling from Detroit to Knoxville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in Detroit and Knoxville?
Frequently asked questions on the trip Detroit, MI - Knoxville, TN
How far is Detroit from Knoxville?
Detroit and Knoxville are 714 km (443 miles) apart.
What are the departure and arrival locations for buses traveling from Detroit to Knoxville?
Buses departing from Detroit Bus Station in Detroit will take you to 100 Kirkwood St in Knoxville.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Detroit, MI to Knoxville, TN was searched and found on Sep 8, 2025 with a price of US$60To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Detroit, MI to Knoxville, TN, as early as possible.
You can expect to pay from US$60 to US$88 for a bus ticket from Detroit, MI to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at US$60 which is on 2025-09-08.
About Bus Travel
Bus Travel Tips
If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Detroit to Knoxville but it'll also be endearing to native speakers who will surely appreciate your effort.
From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Detroit to Knoxville.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Detroit to Knoxville that are otherwise impossible to come by with a plane.
Tune out to the fine sounds of your best music playlist on your bus trip from Detroit to Knoxville while indulging in miles on end of beautiful scenic views.
Did you know?
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
Top travelled bus routes
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Popular Buses Connecting Detroit
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Buses Going to Detroit
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Popular Buses Connecting Knoxville
Buses Leaving from Knoxville
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Buses Going to Knoxville
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Popular routes in this country
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- New York City - Boston
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