Cheap buses leaving Wednesday
One passenger / one way
- This trip is recommended because it is the: Cheapest + FastestDeparture time: 6 August atDeparture city: ChicagoDeparture location: Downtown Greyhound StationArrival time: 6 August atDestination city: KnoxvilleDestination location: Knoxville Bus StationOperated by: Greyhound Lines, Inc.
Vehicle: BusDuration: - Departure time: 6 August atDeparture city: ChicagoDeparture location: Downtown Greyhound StationArrival time: 7 August atDestination city: KnoxvilleDestination location: Knoxville Bus StationOperated by: Greyhound Lines, Inc.Vehicle: BusDuration:
- Departure time: 6 August atDeparture city: ChicagoDeparture location: Chicago 95Th & Dan RyanArrival time: 7 August atDestination city: KnoxvilleDestination location: Knoxville Bus StationOperated by: Greyhound Lines, Inc.Vehicle: BusDuration:
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Bus Chicago to Knoxville, TN: Trip Overview
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Chicago to Knoxville Bus
Busbud helps you find a bus from Chicago to Knoxville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
We make it our job to connect you with the most dependable bus companies that cover bus service from Chicago to Knoxville.
Whether it is cheap bus tickets or more luxurious buses going to Knoxville from Chicago, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in Chicago and Knoxville?
Frequently asked questions on the trip Chicago - Knoxville, TN
How far is Knoxville from Chicago by coach?
The distance between Chicago and Knoxville by coach is approximately 454 miles (731 km).
What is the best way to go from Chicago to Knoxville without flying?
You have the option to select the coach for your journey on this route. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You might also find carpooling options to travel between the two cities.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to Knoxville, TN was searched and found on 6 Aug 2025 with a price of US$81To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Knoxville, TN as early as possible.
You can expect to pay from US$81 to US$166 for a bus ticket from Chicago to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at US$81, which is on 2025-08-06.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Chicago and Knoxville!
From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Chicago to Knoxville.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Chicago to Knoxville.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Chicago to Knoxville.
Did you know?
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
Top travelled bus routes
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Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.
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Popular Buses Connecting Chicago
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Popular Buses Connecting Knoxville
Buses Leaving from Knoxville
- Bus from Knoxville to Charlotte
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Buses Going to Knoxville
- Bus from Nashville to Knoxville
- Coach Memphis - Knoxville
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- Chicago - Knoxville
- Bus from Tampa to Knoxville
- Coach Richmond - Knoxville
- Bus Greeneville - Knoxville
- Spartanburg - Knoxville
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