Bus Tickets from Chicago to Knoxville, TN

Find affordable bus tickets from Chicago to Knoxville, TN with flexible options. Book your trip now

Join 75M+ travelers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every step.
Cancel anytime and receive a 100% refund, no reason needed.
TodayAug 31
from $93
TomorrowSep 1
from $96
TueSep 2
from $77
WedSep 3
from $70
ThuSep 4
from $71
FriSep 5
from $81
SatSep 6
SunSep 7

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: September 1 at
    Departure city: Chicago
    Departure location: Chicago 95Th & Dan Ryan
    Arrival time: September 2 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: September 1 at
    Departure city: Chicago
    Departure location: Downtown Greyhound Station
    Arrival time: September 1 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 1 at
    Departure city: Chicago
    Departure location: Downtown Greyhound Station
    Arrival time: September 1 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 1 at
    Departure city: Chicago
    Departure location: Downtown Greyhound Station
    Arrival time: September 2 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 1 at
    Departure city: Chicago
    Departure location: Downtown Greyhound Station
    Arrival time: September 2 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Chicago to Knoxville, TN: Trip Overview

Average ticket price$91
Average bus trip duration20h 51m
Number of daily buses9
Earliest bus departure12:30am
Distance453 miles (730 km)
Latest bus departure11:59pm

Chicago to Knoxville Bus

Busbud helps you find a bus from Chicago to Knoxville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Chicago to Knoxville.

Whether it is cheap bus tickets or more luxurious buses going to Knoxville from Chicago, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Chicago - Knoxville, TN

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/29
$119
08/30
$86
Today
$97
09/01
$111
09/02
$87
09/03
$84
09/04
$81
09/05
$83
busbud logoThe cheapest trip from Chicago to Knoxville, TN was searched and found on Sep 4, 2025 with a price of $81

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Knoxville, TN, as early as possible.

You can expect to pay from $81 to $150 for a bus ticket from Chicago to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at $81 which is on 2025-09-04.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Chicago and Knoxville!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Chicago to Knoxville.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Chicago to Knoxville.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Chicago to Knoxville.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Will you be returning to Chicago by bus?

Bus from Knoxville, TN to Chicago

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Buses Connecting Chicago

Buses Leaving from Chicago

Buses Going to Chicago

Popular Buses Connecting Knoxville

Buses Leaving from Knoxville

Buses Going to Knoxville