Bus Tickets from Greenville, SC to Knoxville, TN

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Previously seen trips

One passenger / one way

  • Departure time: September 19 at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: September 19 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: September 19 at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: September 19 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:
  • Departure time: October 18 at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: October 18 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: October 24 at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: October 24 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:
  • Departure time: October 26 at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: October 26 at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:

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Bus Greenville, SC to Knoxville, TN: Trip Overview

Average ticket price$65
Average bus trip duration7h 5m
Number of daily buses1
Earliest bus departure2:45pm
Distance120 miles (193 km)

Greenville to Knoxville Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Greenville to Knoxville.

Bus service from Greenville to Knoxville will be provided by the most trusted bus companies.

Discover how much the bus trip from Greenville to Knoxville will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip Greenville, SC - Knoxville, TN

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09/01
$55
09/02
$43
Today
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busbud logoThe cheapest trip from Greenville, SC to Knoxville, TN was searched and found on Sep 2, 2025 with a price of $43

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Knoxville, TN, as early as possible.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Greenville to Knoxville but it'll also be endearing to native speakers who will surely appreciate your effort.

Much more than a mere vehicle taking you from Greenville to Knoxville, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Greenville to Knoxville will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from Greenville to Knoxville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Greenville, SC by bus?

Bus from Knoxville, TN to Greenville, SC

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