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- This trip is recommended because it is: Cheapest + FastestDeparture time: September 4 atDeparture city: KnoxvilleDeparture location: Knoxville Bus StationArrival time: September 5 atDestination city: GreenvilleDestination location: 1116 Woodruff RdOperated by: Greyhound Lines, Inc.
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Bus Knoxville, TN to Greenville, SC: Trip Overview
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Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Knoxville to Greenville Bus
With Busbud, comparing and booking tickets for a bus from Knoxville to Greenville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
We make it our job to connect you with the most dependable bus companies that cover bus service from Knoxville to Greenville.
Whether it is cheap bus tickets or more luxurious buses going to Greenville from Knoxville, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in Knoxville and Greenville?
Frequently asked questions for your trip Knoxville, TN - Greenville, SC
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Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Greenville, SC was searched and found on Sep 3, 2025 with a price of $66To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Greenville, SC, as early as possible.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while traveling from Knoxville to Greenville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Knoxville to Greenville.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Knoxville to Greenville.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Knoxville to Greenville.
Did you know?
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
Top traveled bus routes
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Busbud makes bus travel easy. We help travelers find a bus, plot routes, and book intercity bus tickets all over the world. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.
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Popular Buses Connecting Knoxville
Buses Leaving from Knoxville
- Bus from Knoxville to Charlotte
- Bus Knoxville - Marathon
- Knoxville - Lexington
- Bus from Knoxville to Orlando
- Bus Knoxville - Chicago
- Knoxville - Greenville
- Bus from Knoxville to Nashville
- Bus Knoxville - Atlanta
- Knoxville - Memphis
- Bus from Knoxville to New York City
- Bus Knoxville - Washington
- Knoxville - Asheville
- Bus from Knoxville to Miami
- Bus Knoxville - Jackson
- Knoxville - Cincinnati
Buses Going to Knoxville
- Bus from Nashville to Knoxville
- Bus Memphis - Knoxville
- Charlotte - Knoxville
- Bus from Chicago to Knoxville
- Bus Tampa - Knoxville
- Richmond - Knoxville
- Bus from Atlanta to Knoxville
- Bus Asheville - Knoxville
- New York City - Knoxville
- Bus from Greenville to Knoxville
- Bus Louisville - Knoxville
- Cookeville - Knoxville
- Bus from Lexington to Knoxville
- Bus Dallas - Knoxville
- Dayton - Knoxville
Popular Buses Connecting Greenville
Buses Leaving from Greenville
- Bus from Greenville to Charleston
- Bus Greenville - Spartanburg
- Greenville - Charleston
- Bus from Greenville to Greensboro
- Bus Greenville - Chicago
- Greenville - Miami
- Bus from Greenville to Atlanta
- Bus Greenville - Charlotte
- Greenville - New York City
- Bus from Greenville to Knoxville
- Bus Greenville - Tarboro
- Greenville - Anderson
- Bus from Greenville to Macon
- Bus Greenville - Orlando
- Greenville - Dallas
Buses Going to Greenville
- Bus from Atlanta to Greenville
- Bus Burlington - Greenville
- Nashville - Greenville
- Bus from Knoxville to Greenville
- Bus Savannah - Greenville
- Orlando - Greenville
- Bus from Charlotte to Greenville
- Bus Charleston - Greenville
- Anderson - Greenville
- Bus from Asheville to Greenville
- Bus New York City - Greenville
- LaGrange - Greenville
- Bus from Miami to Greenville
- Bus Fayetteville - Greenville
- Spartanburg - Greenville
Popular routes in this country
- Bus from Fort Lauderdale to Orlando
- Bus Dallas - Houston
- Albany - New York City
- Bus from Las Vegas to Los Angeles
- Bus Tampa - Miami
- Miami - Tampa
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- Dallas - Austin
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- Bus Austin - Houston
- Orlando - Atlanta
- Bus from Dallas to San Antonio
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- New York City - Los Angeles