Find coaches from Knoxville, TN to Greenville, SC

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Mon23 Jun
from US$172
Tue24 Jun
Wed25 Jun
from US$143
Thu26 Jun
from US$156
Fri27 Jun
Sat28 Jun
from US$116
Sun29 Jun
Mon30 Jun

Cheap buses leaving Wednesday

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: 25 June at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: 26 June at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Bus Knoxville to Greenville: Trip Overview

Average ticket priceUS$96
Average bus trip duration12h 5m
Number of daily buses1
Earliest bus departure19:20
Distance120 miles
Latest bus departure19:25

Knoxville to Greenville Bus

With Busbud, comparing and booking tickets for a bus from Knoxville to Greenville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Knoxville to Greenville.

Whether it is cheap bus tickets or more luxurious buses going to Greenville from Knoxville, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Knoxville, TN - Greenville, SC

  1. How far is Greenville from Knoxville by coach?

    The distance between Knoxville and Greenville by coach is approximately 115 miles (186 km).

  2. Is there a way to reach Greenville from Knoxville without a car?

    You can travel to Greenville from Knoxville by coach, which provides a smooth ride and an affordable and convenient trip. Depending on your preferences, carpooling can also be considered as an option.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
19/06
US$70
20/06
No data
Today
No data
22/06
No data
23/06
US$164
24/06
No data
25/06
US$135
26/06
US$148
busbud logoThe cheapest trip from Knoxville to Greenville was searched and found on 19 Jun 2025 with a price of US$70

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville to Greenville as early as possible.

You can expect to pay from US$70 to US$164 for a bus ticket from Knoxville to Greenville based on the last 2 days. You can expect to find the cheapest price for the trip at US$135, which is on 2025-06-25.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Knoxville to Greenville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Knoxville to Greenville.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Knoxville to Greenville.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Knoxville to Greenville.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Will you be returning to Knoxville by bus?

Bus from Knoxville to Greenville

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