Find coaches from Columbus, OH to Knoxville, TN

Next departures

Next departures from Columbus to Knoxville on 3 September
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.
Columbus (E Mound St)
Knoxville Bus StationCheapest
FlixBus + Greyhound Lines, Inc.
100 E Rich St
Knoxville Bus StationFastest
FlixBus + Greyhound Lines, Inc.
100 E Rich St
Knoxville Bus StationNo tags
Greyhound Lines, Inc.
Columbus (E Mound St)
Knoxville Bus StationNo tags

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Bus Columbus, OH to Knoxville, TN: Trip Overview

Average ticket priceUS$68
Average bus trip duration13h 45m
Number of daily buses3
Earliest bus departure00:45
Distance278 miles
Latest bus departure09:45

Columbus to Knoxville Bus

With Busbud, comparing and booking tickets for a bus from Columbus to Knoxville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Columbus to Knoxville from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Knoxville from Columbus, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Columbus, OH - Knoxville, TN

  1. How far is Knoxville from Columbus by coach?

    The distance between Columbus and Knoxville by coach is approximately 281 miles (453 km).

  2. Is there a way to reach Knoxville from Columbus without flying?

    You can choose the coach to travel this route. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You also have the option of utilising carpooling services.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
29/08
US$108
30/08
US$54
Today
US$115
01/09
US$94
02/09
US$61
03/09
US$52
04/09
US$52
05/09
US$62
busbud logoThe cheapest trip from Columbus, OH to Knoxville, TN was searched and found on 3 Sept 2025 with a price of US$52

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Columbus, OH to Knoxville, TN as early as possible.

You can expect to pay from US$52 to US$127 for a bus ticket from Columbus, OH to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at US$52, which is on 2025-09-03.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Columbus to Knoxville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Columbus to Knoxville, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Columbus to Knoxville.

Make a music playlist for your bus ride from Columbus to Knoxville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to Columbus, OH by bus?

Bus from Knoxville, TN to Columbus, OH

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

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