Bus Tickets from Greenville, SC to Chicago

Next departures

Next departures for Greenville to Chicago on September 5
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus
1116 Woodruff Rd
Chicago 95Th & Dan RyanCheapest
FlixBus + Greyhound Lines, Inc.
1116 Woodruff Rd
537-517 W. Jackson BlvdFastest
FlixBus
1116 Woodruff Rd
Downtown Greyhound StationNo tags
FlixBus + Greyhound Lines, Inc.
1116 Woodruff Rd
Downtown Greyhound StationNo tags
Greyhound Lines, Inc.
1116 Woodruff Rd
537-517 W. Jackson BlvdNo tags

Accepted payments

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  • JCB payment
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Compare 2 ways to go from Greenville to Chicago.

Bus
Average Price$85 - $314Average Duration21h 25m
22kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average Price$177 - $533Average Duration1d 7h
82kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Greenville to Chicago

Among the sustainable travel choices, the bus stands out as the good way to reach Chicago. The journey takes about 21 hours 25 minutes and with fares starting at just $85, it presents an excellent value for a comfortable ride.

13bus per day
21h 25mAverage Duration
$85Cheapest ticket
22kgCO₂ emissions

Bus Greenville, SC to Chicago: Trip Overview

Average ticket price$123
Average bus trip duration21h 25m
Number of daily buses13
Earliest bus departure8:40am
Distance556 miles (896 km)
Latest bus departure10:00pm

Greenville to Chicago Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Greenville to Chicago.

We make it our job to connect you with the most dependable bus companies that cover bus service from Greenville to Chicago.

Whether it is cheap bus tickets or more luxurious buses going to Chicago from Greenville, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Greenville, SC - Chicago

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/31
$91
09/01
$122
Today
No data
09/03
$81
09/04
No data
09/05
$86
09/06
$97
09/07
$86
busbud logoThe cheapest trip from Greenville, SC to Chicago was searched and found on Sep 3, 2025 with a price of $81

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Chicago, as early as possible.

You can expect to pay from $81 to $239 for a bus ticket from Greenville, SC to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $81 which is on 2025-09-03.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Greenville to Chicago but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Greenville to Chicago.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Greenville to Chicago.

Make a music playlist for your bus ride from Greenville to Chicago, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

What's the cheapest way to go from Greenville, SC to Chicago?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Greenville, SC by bus?

Bus from Chicago to Greenville, SC

You can also go to Chicago by train

Train from Greenville, SC to Chicago

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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