Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
With Busbud, comparing and booking tickets for a bus from Chicago to Columbia is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
Bus service from Chicago to Columbia will be provided by the most trusted bus companies.
Whether it is cheap bus tickets or more luxurious buses going to Columbia from Chicago, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in Chicago and Columbia?
Frequently asked questions for your trip Chicago - Columbia, MO
What is the distance between Chicago and Columbia?
The distance between the two cities is 318 miles (512 km).
What are the departure and arrival stations when taking the bus from Chicago to Columbia?
If you're headed to Columbia from Chicago, chances are that your bus will depart from Downtown Greyhound Station and arrive at Midway Truck Plaza Bus Stop. These are the primary departure and arrival locations on this route, but you can also find other options that could better fit your plans.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
08/20
$73
08/21
$53
Today
$68
08/23
$66
08/24
$95
08/25
$56
08/26
$51
08/27
$49
The cheapest trip from Chicago to Columbia, MO was searched and found on Aug 27, 2025 with a price of $49
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Columbia, MO, as early as possible.
You can expect to pay from $49 to $105 for a bus ticket from Chicago to Columbia, MO based on the last 2 days. You can expect to find the cheapest price for the trip at $49 which is on 2025-08-27.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while traveling from Chicago to Columbia.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Much more than a mere vehicle taking you from Chicago to Columbia, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Chicago to Columbia.
Tune out to the fine sounds of your best music playlist on your bus trip from Chicago to Columbia while indulging in miles on end of beautiful scenic views.
Did you know?
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.
Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.
The cheapest trip from Chicago to Columbia, MO was searched and found on Aug 27, 2025 with a price of $49
