Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Rochester | 1116 Woodruff Rd | Cheapest | |||||
FlixBus + Greyhound Lines, Inc. | Rochester | 1116 Woodruff Rd | Fastest | |||||
 | Rochester | 1116 Woodruff Rd | No tags | |||||
| Rochester | 1116 Woodruff Rd | No tags |
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Compare 2 ways to go from Rochester to Greenville.
Busbud recommends taking the bus from Rochester to GreenvilleAmong the sustainable travel choices, the bus stands out as the good way to reach Greenville. The journey takes about 23 hours 30 minutes and with fares starting at just $62, it presents an excellent value for a comfortable ride.
Bus Rochester, NY, US to Greenville, SC: Trip Overview
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Rochester to Greenville Bus
Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Rochester to Greenville.
We make it our job to connect you with the most dependable bus companies that cover bus service from Rochester to Greenville.
From cheap bus tickets to more luxurious buses traveling from Rochester to Greenville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in Rochester and Greenville?
Frequently asked questions for your trip Rochester, NY, US - Greenville, SC
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Rochester, NY, US to Greenville, SC was searched and found on Sep 22, 2025 with a price of $67To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rochester, NY, US to Greenville, SC, as early as possible.
You can expect to pay from $67 to $99 for a bus ticket from Rochester, NY, US to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $67 which is on 2025-09-22.
About Bus Travel
Bus Travel Tips
If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Rochester to Greenville but it'll also be endearing to native speakers who will surely appreciate your effort.
From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Rochester to Greenville.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Rochester to Greenville that are otherwise impossible to come by with a plane.
Make a music playlist for your bus ride from Rochester to Greenville, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!
The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
What's the cheapest way to go from Rochester, NY, US to Greenville, SC?
The bus is the cheapest travel choice for this destinationTop traveled bus routes
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Popular Buses Connecting Rochester
Buses Leaving from Rochester
- Bus from Rochester to New York City
- Bus Rochester - Indiana
- Rochester - Victoria
- Bus from Rochester to Albany
- Bus Rochester - Albany
- Rochester - London
- Bus from Rochester to Geneva
- Bus Rochester - Ithaca
- Rochester - Buffalo
- Bus from Rochester to Elmira
- Bus Rochester - Watertown
- Rochester - Boston
- Bus from Rochester to Niagara Falls
- Bus Rochester - Newark
- Rochester - Syracuse
Buses Going to Rochester
- Bus from Washington to Rochester
- Bus Victoria - Rochester
- Syracuse - Rochester
- Bus from Minneapolis to Rochester
- Bus Boston - Rochester
- Chicago - Rochester
- Bus from New York City to Rochester
- Bus Geneva - Rochester
- Elmira - Rochester
- Bus from Buffalo to Rochester
- Bus Albany - Rochester
- Geneseo - Rochester
- Bus from Oneonta to Rochester
- Bus Ithaca - Rochester
- Newark - Rochester
Popular Buses Connecting Greenville
Buses Leaving from Greenville
- Bus from Greenville to Charleston
- Bus Greenville - Spartanburg
- Greenville - Charleston
- Bus from Greenville to Greensboro
- Bus Greenville - Miami
- Greenville - Chicago
- Bus from Greenville to Charlotte
- Bus Greenville - Atlanta
- Greenville - New York City
- Bus from Greenville to Knoxville
- Bus Greenville - Anderson
- Greenville - Tarboro
- Bus from Greenville to Macon
- Bus Greenville - Dallas
- Greenville - Orlando
Buses Going to Greenville
- Bus from Atlanta to Greenville
- Bus Burlington - Greenville
- Nashville - Greenville
- Bus from Knoxville to Greenville
- Bus Orlando - Greenville
- Savannah - Greenville
- Bus from Charlotte to Greenville
- Bus Charleston - Greenville
- Anderson - Greenville
- Bus from Asheville to Greenville
- Bus New York City - Greenville
- Miami - Greenville
- Bus from Fayetteville to Greenville
- Bus Spartanburg - Greenville
- Myrtle Beach - Greenville
Popular routes in this country
- Bus from Fort Lauderdale to Orlando
- Bus Dallas - Houston
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- Bus from Las Vegas to Los Angeles
- Bus Tampa - Miami
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- Miami - Tampa
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- Orlando - Atlanta
- Bus from Houston to Austin
- Bus San Antonio - Houston
- Atlanta - Orlando