Find coaches from Rochester, NY, US to Greenville, SC

Today30 Jul
from US$166
Tomorrow31 Jul
from US$138
Fri1 Aug
Sat2 Aug
Sun3 Aug
Mon4 Aug
Tue5 Aug
from US$114
Wed6 Aug

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 31 July at
    Departure city: Rochester
    Departure location: Rochester
    Arrival time: 1 August at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 31 July at
    Departure city: Rochester
    Departure location: Rochester
    Arrival time: 1 August at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 31 July at
    Departure city: Rochester
    Departure location: Rochester
    Arrival time: 1 August at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: 31 July at
    Departure city: Rochester
    Departure location: Rochester
    Arrival time: 1 August at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 31 July at
    Departure city: Rochester
    Departure location: Rochester
    Arrival time: 2 August at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:

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Compare 2 ways to travel from Rochester to Greenville

Bus
Average priceUS$106 - US$248Average duration23h 30m
25kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average priceUS$251 - US$525Average duration23h 51m
92kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Rochester to Greenville

Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 23 hours 30 minutes and with fares starting at just US$106, it presents an excellent value for a comfortable ride.

3bus per day
23h 30mAverage duration
US$106Cheapest ticket
25kgCO₂ emissions

Bus Rochester, NY, US to Greenville, SC: Trip Overview

Average ticket priceUS$165
Average bus trip duration23h 30m
Number of daily buses3
Earliest bus departure09:05
Distance627 miles
Latest bus departure23:50

Rochester to Greenville Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Rochester to Greenville.

We make it our job to connect you with the most dependable bus companies that cover bus service from Rochester to Greenville.

From cheap bus tickets to more luxurious buses travelling from Rochester to Greenville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Rochester, NY, US - Greenville, SC

  1. What's the distance between Rochester and Greenville by coach?

    The journey from Rochester to Greenville by coach covers an approximate distance of 628 miles (1012 km).

  2. How can I travel from Rochester to Greenville avoiding air travel?

    To travel from Rochester to Greenville without flying, you can take the coaches. The coach ensures a pleasant travel experience, granting you the opportunity to appreciate the scenery as you make your way to your final stop. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
28/07
No data
29/07
US$139
Today
US$143
31/07
US$157
01/08
No data
02/08
No data
03/08
No data
04/08
No data
busbud logoThe cheapest trip from Rochester, NY, US to Greenville, SC was searched and found on 29 Jul 2025 with a price of US$139

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rochester, NY, US to Greenville, SC as early as possible.

You can expect to pay from US$139 to US$193 for a bus ticket from Rochester, NY, US to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at US$157, which is on 2025-07-31.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Rochester to Greenville but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Rochester to Greenville.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Rochester to Greenville that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Rochester to Greenville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

What's the cheapest way to go from Rochester, NY, US to Greenville, SC?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Rochester, NY, US by bus?

Bus from Rochester, NY, US to Greenville, SC

You can also go to Greenville, SC by train

Train from Rochester, NY, US to Greenville, SC

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

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