Find coaches from St. Louis to San Diego, CA, US

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Today8 Sept
Tomorrow9 Sept
from US$171
Wed10 Sept
Thu11 Sept
Fri12 Sept
Sat13 Sept
from US$163
Sun14 Sept
Mon15 Sept

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 9 September at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: 11 September at
    Destination city: San Diego
    Destination location: 5716 Hardy Ave
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 9 September at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: 10 September at
    Destination city: San Diego
    Destination location: UCSD Health La Jolla Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: 9 September at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: 10 September at
    Destination city: San Diego
    Destination location: San Diego (Old Town-FlixBus)
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: 9 September at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: 10 September at
    Destination city: San Diego
    Destination location: Greyhound Bus Stop
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 9 September at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: 11 September at
    Destination city: San Diego
    Destination location: San Diego (Old Town-FlixBus)
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:

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Compare 2 ways to travel from St. Louis to San Diego

Bus
Average priceUS$132 - US$426Average duration2d 3h
63kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average priceUS$219 - US$513Average duration2d 8h
229kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from St. Louis to San Diego

Among the sustainable travel choices, the bus stands out as a good way to reach San Diego. The journey takes about 2 days, 3 hours 30 minutes and with fares starting at just US$132, it presents an excellent value for a comfortable ride.

16bus per day
2d 3hAverage duration
US$132Cheapest ticket
63kgCO₂ emissions

Bus St. Louis to San Diego, CA, US: Trip Overview

Average ticket priceUS$188
Average bus trip duration2d 3h
Number of daily buses16
Earliest bus departure01:15
Distance1559 miles
Latest bus departure23:30

St. Louis to San Diego Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from St. Louis to San Diego.

We make sure you can find a bus service from St. Louis to San Diego from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to San Diego from St. Louis, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip St. Louis - San Diego, CA, US

  1. How far is San Diego from St. Louis by coach?

    The journey from St. Louis to San Diego by coach covers an approximate distance of 1560 miles (2516 km).

  2. Is there a way to reach San Diego from St. Louis without flying?

    To travel from St. Louis to San Diego without flying, you can take the coaches. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You also have the option of utilising carpooling services.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06/09
US$180
07/09
US$159
Today
No data
09/09
US$168
10/09
No data
11/09
No data
12/09
US$158
13/09
US$158
busbud logoThe cheapest trip from St. Louis to San Diego, CA, US was searched and found on 13 Sept 2025 with a price of US$158

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to San Diego, CA, US as early as possible.

You can expect to pay from US$158 to US$188 for a bus ticket from St. Louis to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$158, which is on 2025-09-13.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from St. Louis to San Diego but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from St. Louis to San Diego, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St. Louis to San Diego.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from St. Louis to San Diego.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

What's the cheapest way to go from St. Louis to San Diego, CA, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to St. Louis by bus?

Bus from San Diego, CA, US to St. Louis

You can also go to San Diego, CA, US by train

Train from St. Louis to San Diego, CA, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

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