Bus Tickets from St. Louis to San Diego, CA, US

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TodaySep 7
from $145
TomorrowSep 8
TueSep 9
from $171
WedSep 10
ThuSep 11
FriSep 12
SatSep 13
from $163
SunSep 14

Cheap buses leaving Tuesday

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: September 9 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: September 11 at
    Destination city: San Diego
    Destination location: 5716 Hardy Ave
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: September 9 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: September 10 at
    Destination city: San Diego
    Destination location: UCSD Health La Jolla Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: September 9 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: September 10 at
    Destination city: San Diego
    Destination location: San Diego (Old Town-FlixBus)
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: September 9 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: September 10 at
    Destination city: San Diego
    Destination location: Greyhound Bus Stop
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 9 at
    Departure city: St. Louis
    Departure location: Gateway Station
    Arrival time: September 11 at
    Destination city: San Diego
    Destination location: San Diego (Old Town-FlixBus)
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:

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Compare 2 ways to go from St. Louis to San Diego.

Bus
Average Price$132 - $426Average Duration2d 3h
63kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average Price$219 - $513Average Duration2d 8h
229kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from St. Louis to San Diego

Among the sustainable travel choices, the bus stands out as the good way to reach San Diego. The journey takes about 2 days, 3 hours 30 minutes and with fares starting at just $132, it presents an excellent value for a comfortable ride.

16bus per day
2d 3hAverage Duration
$132Cheapest ticket
63kgCO₂ emissions

Bus St. Louis to San Diego, CA, US: Trip Overview

Average ticket price$188
Average bus trip duration2d 3h
Number of daily buses16
Earliest bus departure1:15am
Distance1559 miles (2514 km)
Latest bus departure11:30pm

St. Louis to San Diego Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from St. Louis to San Diego.

We make sure you can find a bus service from St. Louis to San Diego from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to San Diego from St. Louis, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip St. Louis - San Diego, CA, US

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09/05
$181
09/06
$180
Today
$159
09/08
No data
09/09
$168
09/10
No data
09/11
No data
09/12
$158
busbud logoThe cheapest trip from St. Louis to San Diego, CA, US was searched and found on Sep 12, 2025 with a price of $158

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to San Diego, CA, US, as early as possible.

You can expect to pay from $158 to $181 for a bus ticket from St. Louis to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $158 which is on 2025-09-12.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from St. Louis to San Diego but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from St. Louis to San Diego, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St. Louis to San Diego.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from St. Louis to San Diego.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

What's the cheapest way to go from St. Louis to San Diego, CA, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to St. Louis by bus?

Bus from San Diego, CA, US to St. Louis

You can also go to San Diego, CA, US by train

Train from St. Louis to San Diego, CA, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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