Bus Tickets from Chicago to San Diego, CA, US

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TodayJul 26
from $284
TomorrowJul 27
from $191
MonJul 28
from $184
TueJul 29
WedJul 30
ThuJul 31
FriAug 1
SatAug 2

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: July 27 at
    Departure city: Chicago
    Departure location: 537-517 W. Jackson Blvd
    Arrival time: July 30 at
    Destination city: San Diego
    Destination location: Downtown SD (Seaport)
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: July 27 at
    Departure city: Chicago
    Departure location: Chicago 95Th & Dan Ryan
    Arrival time: July 29 at
    Destination city: San Diego
    Destination location: UCSD Health La Jolla Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: July 27 at
    Departure city: Chicago
    Departure location: Downtown Greyhound Station
    Arrival time: July 29 at
    Destination city: San Diego
    Destination location: San Diego (Old Town-FlixBus)
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: July 27 at
    Departure city: Chicago
    Departure location: 537-517 W. Jackson Blvd
    Arrival time: July 29 at
    Destination city: San Diego
    Destination location: Greyhound Bus Stop
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: July 27 at
    Departure city: Chicago
    Departure location: Downtown Greyhound Station
    Arrival time: July 29 at
    Destination city: San Diego
    Destination location: San Diego (Old Town-FlixBus)
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

Accepted payments

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Compare 2 ways to go from Chicago to San Diego.

Bus
Average Price$108 - $729Average Duration2d 8h
70kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average Price$345 - $345Average Duration2d 17h
254kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Chicago to San Diego

Among the sustainable travel choices, the bus stands out as the good way to reach San Diego. The journey takes about 2 days, 8 hours 15 minutes and with fares starting at just $108, it presents an excellent value for a comfortable ride.

22bus per day
2d 8hAverage Duration
$108Cheapest ticket
70kgCO₂ emissions

Bus Chicago to San Diego, CA, US: Trip Overview

Average ticket price$179
Average bus trip duration2d 8h
Number of daily buses22
Earliest bus departure12:15am
Distance1727 miles (2785 km)
Latest bus departure11:50pm

Chicago to San Diego Bus

Busbud helps you find a bus from Chicago to San Diego. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from Chicago to San Diego will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses traveling from Chicago to San Diego, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip Chicago - San Diego, CA, US

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
07/24
$190
07/25
$389
Today
$226
07/27
$216
07/28
$191
07/29
$134
07/30
$176
07/31
$196
busbud logoThe cheapest trip from Chicago to San Diego, CA, US was searched and found on Jul 29, 2025 with a price of $134

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to San Diego, CA, US, as early as possible.

You can expect to pay from $134 to $435 for a bus ticket from Chicago to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $134 which is on 2025-07-29.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Chicago and San Diego!

Much more than a mere vehicle taking you from Chicago to San Diego, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Chicago to San Diego that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Chicago to San Diego, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

What's the cheapest way to go from Chicago to San Diego, CA, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Chicago by bus?

Bus from Chicago to San Diego, CA, US

You can also go to San Diego, CA, US by train

Train from Chicago to San Diego, CA, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

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Popular bus departures from Chicago

Popular bus departures to Chicago

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