Find coaches from Jacksonville, FL to Knoxville, TN

Find affordable coach tickets from Jacksonville, FL to Knoxville, TN with flexible options. Book your journey now

Join 75M+ travellers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every stage.
Cancel anytime and receive a 100% refund, no reason needed.
Today19 Jun
Tomorrow20 Jun
from US$105
Sat21 Jun
Sun22 Jun
from US$121
Mon23 Jun
from US$159
Tue24 Jun
Wed25 Jun
from US$115
Thu26 Jun

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 20 June at
    Departure city: Jacksonville
    Departure location: Jacksonville Bus Station
    Arrival time: 21 June at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 20 June at
    Departure city: Jacksonville
    Departure location: Jacksonville Bus Station
    Arrival time: 20 June at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 20 June at
    Departure city: Jacksonville
    Departure location: Jacksonville Bus Station
    Arrival time: 20 June at
    Destination city: Knoxville
    Destination location: Knoxville Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Jacksonville to Knoxville: Trip Overview

Average ticket priceUS$121
Average bus trip duration13h 45m
Number of daily buses2
Earliest bus departure08:05
Distance412 miles
Latest bus departure21:45

Jacksonville to Knoxville Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Jacksonville to Knoxville.

We make sure you can find a bus service from Jacksonville to Knoxville from the most reliable bus companies operating this trip.

Discover how much the bus trip from Jacksonville to Knoxville will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Jacksonville, FL - Knoxville, TN

  1. How far is Knoxville from Jacksonville by coach?

    The journey from Jacksonville to Knoxville by coach covers an approximate distance of 410 miles (662 km).

  2. What is the best way to go from Jacksonville to Knoxville without flying?

    To travel from Jacksonville to Knoxville without flying, you can take the coaches. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You also have the option of utilising carpooling services.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
17/06
No data
18/06
US$108
Today
No data
20/06
No data
21/06
No data
22/06
No data
23/06
US$151
24/06
No data
busbud logoThe cheapest trip from Jacksonville to Knoxville was searched and found on 18 Jun 2025 with a price of US$108

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Jacksonville to Knoxville as early as possible.

You can expect to pay from US$108 to US$151 for a bus ticket from Jacksonville to Knoxville based on the last 2 days. You can expect to find the cheapest price for the trip at US$151, which is on 2025-06-23.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Jacksonville to Knoxville but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Jacksonville to Knoxville, get comfy and count the stars.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Jacksonville to Knoxville will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Make a music playlist for your bus ride from Jacksonville to Knoxville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Jacksonville by bus?

Bus from Jacksonville to Knoxville

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Buses Connecting Jacksonville

Buses Leaving from Jacksonville

Buses Going to Jacksonville

Popular Buses Connecting Knoxville

Buses Leaving from Knoxville

Buses Going to Knoxville