Bus Tickets from Knoxville, TN to Panama City, US

Previously seen trips

Next departures for Knoxville to Panama City on September 23
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound
Knoxville Bus Station
Panama City Beach StationNo tags
Greyhound
Knoxville Bus Station
Panama City Beach StationNo tags
Greyhound
Knoxville Bus Station
Panama City Beach StationNo tags
Greyhound
Knoxville Bus Station
Panama City Beach StationNo tags
Greyhound
Knoxville Bus Station
Panama City Beach StationNo tags

Accepted payments

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Bus Knoxville, TN to Panama City, US: Trip Overview

Average Ticket PriceUS$87
Average Bus Trip Duration18h 10m
Number of daily buses1
Earliest bus departure7:25pm
Distance670 km

Knoxville to Panama City Bus

Busbud helps you find a bus from Knoxville to Panama City. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Knoxville to Panama City.

Discover how much the bus trip from Knoxville to Panama City will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Knoxville, TN - Panama City, US

  1. What is the travel distance from Knoxville to Panama City?

    The distance between Knoxville and Panama City is around 666 km (413 miles).

  2. What are the departure and arrival locations for buses traveling from Knoxville to Panama City?

    Buses traveling this route start their trip at 100 Kirkwood St, in Knoxville, and end it at Panama City Greyhound Bus Station, in Panama City.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09-21
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09-22
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Today
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09-24
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09-25
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09-26
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09-28
US$59
busbud logoThe cheapest trip from Knoxville, TN to Panama City, US was searched and found on Sep 28, 2025 with a price of US$59

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Panama City, US, as early as possible.

You can expect to pay from US$59 to US$59 for a bus ticket from Knoxville, TN to Panama City, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$59 which is on 2025-09-28.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Knoxville and Panama City!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Knoxville to Panama City.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Knoxville to Panama City will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from Knoxville to Panama City, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

Will you be returning to Knoxville, TN by bus?

Bus from Panama City, US to Knoxville, TN

Why choose Busbud?

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