Bus Tickets from Chicago to Panama City, US

Find affordable bus tickets from Chicago to Panama City, US with flexible options. Book your trip now

Join 75M+ travelers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every step.
Cancel anytime and receive a 100% refund, no reason needed.

Previously seen trips

One passenger / one way

  • Departure time: September 16 at
    Departure city: Chicago
    Departure location: Downtown Greyhound Station
    Arrival time: September 17 at
    Destination city: Panama City
    Destination location: Panama City Beach Station
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: September 16 at
    Departure city: Chicago
    Departure location: 537-517 W. Jackson Blvd
    Arrival time: September 17 at
    Destination city: Panama City
    Destination location: Panama City Beach Station
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: September 16 at
    Departure city: Chicago
    Departure location: Chicago 95Th & Dan Ryan
    Arrival time: September 18 at
    Destination city: Panama City
    Destination location: Panama City Beach Station
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: September 18 at
    Departure city: Chicago
    Departure location: Chicago 95Th & Dan Ryan
    Arrival time: September 20 at
    Destination city: Panama City
    Destination location: Panama City Beach Station
    Operated by: Greyhound + FlixBus
    Greyhound + FlixBus
    Vehicle: BusDuration:
  • Departure time: September 18 at
    Departure city: Chicago
    Departure location: 537-517 W. Jackson Blvd
    Arrival time: September 20 at
    Destination city: Panama City
    Destination location: Panama City Beach Station
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Chicago to Panama City, US: Trip Overview

Average Ticket PriceUS$126
Average Bus Trip Duration1d 6h
Number of daily buses9
Earliest bus departure12:30am
Distance1293 km
Latest bus departure11:59pm

Chicago to Panama City Bus

With Busbud, comparing and booking tickets for a bus from Chicago to Panama City is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Chicago to Panama City will be provided by the most trusted bus companies.

Discover how much the bus trip from Chicago to Panama City will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Chicago - Panama City, US

  1. What is the travel distance from Chicago to Panama City?

    Chicago and Panama City are 1314 km (815 miles) apart.

  2. What are the departure and arrival locations for buses traveling from Chicago to Panama City?

    Buses departing from Downtown Greyhound Station in Chicago will take you to Panama City Greyhound Bus Station in Panama City.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-31
US$148
09-01
US$134
Today
No data
09-03
No data
09-04
No data
09-05
No data
09-06
No data
09-07
US$169
busbud logoThe cheapest trip from Chicago to Panama City, US was searched and found on Sep 1, 2025 with a price of US$134

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Panama City, US, as early as possible.

You can expect to pay from US$134 to US$181 for a bus ticket from Chicago to Panama City, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$169 which is on 2025-09-07.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Chicago to Panama City.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Chicago to Panama City, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Chicago to Panama City will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from Chicago to Panama City, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to Chicago by bus?

Bus from Panama City, US to Chicago

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Buses Connecting Chicago

Buses Leaving from Chicago

Buses Going to Chicago

Popular Buses Connecting Panama City

Buses Leaving from Panama City

Buses Going to Panama City