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- This trip is recommended because it is the: Cheapest
- This trip is recommended because it is the: FastestDeparture time: 3 August atDeparture city: ChicagoDeparture location: Chicago 95Th & Dan RyanArrival time: 4 August atDestination city: Panama CityDestination location: Panama City Beach StationOperated by: Greyhound Lines, Inc.
Vehicle: BusDuration: - Departure time: 3 August atDeparture city: ChicagoDeparture location: Downtown Greyhound StationArrival time: 4 August atDestination city: Panama CityDestination location: Panama City Beach StationOperated by: Greyhound Lines, Inc.Vehicle: BusDuration:
- Departure time: 3 August atDeparture city: ChicagoDeparture location: Downtown Greyhound StationArrival time: 4 August atDestination city: Panama CityDestination location: Panama City Beach StationOperated by: Greyhound Lines, Inc.Vehicle: BusDuration:
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Bus Chicago to Panama City, US: Trip Overview
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Chicago to Panama City Bus
With Busbud, comparing and booking tickets for a bus from Chicago to Panama City is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
Bus service from Chicago to Panama City will be provided by the most trusted bus companies.
Discover how much the bus trip from Chicago to Panama City will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.
Where are the popular stops in Chicago and Panama City?
Frequently asked questions on the trip Chicago - Panama City, US
How far is Panama City from Chicago by coach?
The journey from Chicago to Panama City by coach covers an approximate distance of 815 miles (1314 km).
Is there a way to reach Panama City from Chicago without flying?
To travel from Chicago to Panama City without flying, you can take the coaches. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You might also find carpooling options to travel between the two cities.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to Panama City, US was searched and found on 3 Aug 2025 with a price of US$169To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Panama City, US as early as possible.
You can expect to pay from US$169 to US$367 for a bus ticket from Chicago to Panama City, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$169, which is on 2025-08-03.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while travelling from Chicago to Panama City.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Much more than a mere vehicle taking you from Chicago to Panama City, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.
Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Chicago to Panama City will emit half the CO2 emitted by a train, and radically less than a car or an airplane.
Make a music playlist for your bus ride from Chicago to Panama City, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
Top travelled bus routes
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Popular Buses Connecting Chicago
Buses Leaving from Chicago
Buses Going to Chicago
Popular Buses Connecting Panama City
Buses Leaving from Panama City
- Bus from Panama City to Long Beach
- Coach Panama City - Miami
- Bus Panama City - San Jose
- Panama City - Atlanta
- Bus from Panama City to Orlando
- Coach Panama City - Tallahassee
- Bus Panama City - Columbus
- Panama City - Vienna
- Bus from Panama City to Lima
- Coach Panama City - Fort Lauderdale
- Bus Panama City - Huntsville
- Panama City - Kansas City
- Bus from Panama City to Nashville
- Coach Panama City - Florence
- Bus Panama City - Fayetteville
Buses Going to Panama City
- Bus from Miami to Panama City
- Coach Atlanta - Panama City
- Bus Tampa - Panama City
- Chicago - Panama City
- Bus from San Jose to Panama City
- Coach Houston - Panama City
- Bus Orlando - Panama City
- Boca Raton - Panama City
- Bus from Lima to Panama City
- Coach Austin - Panama City
- Bus Los Angeles - Panama City
- Fort Lauderdale - Panama City
- Bus from Indianapolis to Panama City
- Coach Lake City - Panama City
- Bus Gainesville - Panama City