Bus Tickets from Knoxville (TN) to Indianapolis

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TodayJun 14
from US$119
TomorrowJun 15
MonJun 16
TueJun 17
WedJun 18
from US$84
ThuJun 19
FriJun 20
SatJun 21

Cheap buses leaving Wednesday

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: June 18 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: June 19 at
    Destination city: Indianapolis
    Destination location: Downtown Transit Center
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: June 18 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: June 19 at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 18 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: June 19 at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 18 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: June 19 at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

Last refresh of the prices: Last Wednesday at 5:12 PM EDT.

Prices and availability are subject to change.

Accepted payments

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Bus Knoxville to Indianapolis: Trip Overview

Average Ticket PriceUS$112
Average Bus Trip Duration14h 10m
Number of daily buses3
Earliest bus departure6:15pm
Distance464 km
Latest bus departure7:25pm

Knoxville to Indianapolis Bus

With Busbud, comparing and booking tickets for a bus from Knoxville to Indianapolis is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Knoxville to Indianapolis will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from Knoxville to Indianapolis, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Knoxville (TN) - Indianapolis

  1. How long is the bus trip from Knoxville to Indianapolis?

    The typical travel time from Knoxville to Indianapolis by bus is around 14h 10m. The fastest bus on this trip will get to Indianapolis in 10h 35m

  2. How far is Knoxville from Indianapolis?

    The distance between Knoxville and Indianapolis is around 468 km (290 miles).

  3. What are the departure and arrival locations for buses traveling from Knoxville to Indianapolis?

    Buses traveling this route start their trip at 100 Kirkwood St, in Knoxville, and end it at Greyhound Amtrak Station, in Indianapolis.

  4. What is the cheapest way to travel from Knoxville to Indianapolis?

    The least expensive option to go from Knoxville to Indianapolis would be going by bus. The ticket price for this bus starts at US$75, making this your best choice for this trip.

  5. How much does it cost to take the bus from Knoxville to Indianapolis?

    Taking the bus from Knoxville to Indianapolis costs on average US$112.

  6. Can I take an overnight bus from Knoxville to Indianapolis?

    Yes! Catch buses leaving from Knoxville until 7:25pm and reaching Indianapolis on the following day.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06-12
US$69
06-13
No data
Today
US$111
06-15
No data
06-16
No data
06-17
No data
06-18
US$84
06-19
US$74
busbud logoThe cheapest trip from Knoxville to Indianapolis was searched and found on Jun 12, 2025 with a price of US$69

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville to Indianapolis, as early as possible.

You can expect to pay from US$69 to US$127 for a bus ticket from Knoxville to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at US$74 which is on 2025-06-19.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Knoxville to Indianapolis.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Knoxville to Indianapolis, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Knoxville to Indianapolis that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Knoxville to Indianapolis, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Will you be returning to Knoxville by bus?

Bus from Knoxville to Indianapolis

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