Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Knoxville Bus Station | Indianapolis Bus Station | CheapestFastest | |||||
| Knoxville Bus Station | Indianapolis Bus Station | No tags | |||||
Greyhound Lines, Inc. + FlixBus | Knoxville Bus Station | Downtown Transit Center | No tags |
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Bus Knoxville, TN to Indianapolis: Trip Overview
Compare bus companies
Based on 87262 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at US$62
Greyhound Knoxville Indianapolis recent customer reviews
Was a nice experience, will go greyhound again
Kimberly L.
Knoxville to Indianapolis Bus
With Busbud, comparing and booking tickets for a bus from Knoxville to Indianapolis is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
Bus service from Knoxville to Indianapolis will be provided by the most trusted bus companies.
From cheap bus tickets to more luxurious buses travelling from Knoxville to Indianapolis, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in Knoxville and Indianapolis?
Frequently asked questions on the trip Knoxville, TN - Indianapolis
How far is Knoxville from Indianapolis?
The distance between Knoxville and Indianapolis is around 468 km (290 miles).
What are the departure and arrival locations for buses traveling from Knoxville to Indianapolis?
Buses traveling this route start their trip at 100 Kirkwood St, in Knoxville, and end it at Greyhound Amtrak Station, in Indianapolis.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Indianapolis was searched and found on Sep 19, 2025 with a price of US$57To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Indianapolis, as early as possible.
You can expect to pay from US$57 to US$92 for a bus ticket from Knoxville, TN to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at US$57 which is on 2025-09-19.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while travelling from Knoxville to Indianapolis.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Much more than a mere vehicle taking you from Knoxville to Indianapolis, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Knoxville to Indianapolis that are otherwise impossible to come by with a plane.
Make a music playlist for your bus ride from Knoxville to Indianapolis, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
Top travelled bus routes
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Popular Buses Connecting Knoxville
Buses Leaving from Knoxville
- Bus from Knoxville to Charlotte
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- Bus Knoxville - Atlanta
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Buses Going to Knoxville
- Bus from Nashville to Knoxville
- Bus Memphis - Knoxville
- Charlotte - Knoxville
- Bus from Chicago to Knoxville
- Bus Tampa - Knoxville
- Detroit - Knoxville
- Bus from Fredericksburg to Knoxville
- Bus Orlando - Knoxville
- Indianapolis - Knoxville
- Bus from San Diego to Knoxville
- Bus El Paso - Knoxville
- Lake City - Knoxville
- Bus from Pittsburgh to Knoxville
- Bus Spartanburg - Knoxville
- Austin - Knoxville
Popular Buses Connecting Indianapolis
Buses Leaving from Indianapolis
- Bus from Indianapolis to Muncie
- Bus Indianapolis - Nashville
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- Bus Indianapolis - Detroit
- Indianapolis - Madison
- Bus from Indianapolis to Ashland
- Bus Indianapolis - New York City
- Indianapolis - Cheyenne
Buses Going to Indianapolis
- Bus from South Bend to Indianapolis
- Bus Bloomington - Indianapolis
- Bloomington - Indianapolis
- Bus from Terre Haute to Indianapolis
- Bus Greenfield - Indianapolis
- Merrillville - Indianapolis
- Bus from Chicago to Indianapolis
- Bus St. Louis - Indianapolis
- Detroit - Indianapolis
- Bus from New York City to Indianapolis
- Bus Toledo - Indianapolis
- London - Indianapolis
- Bus from Buffalo to Indianapolis
- Bus Columbus - Indianapolis
- Peoria - Indianapolis
Popular routes in this country
- Bus from Boston to New York City
- Bus Washington - New York City
- New York City - Boston
- Bus from Buffalo to New York City
- Bus Philadelphia - New York City
- Niagara Falls - New York City
- Bus from Baltimore to New York City
- Bus Detroit - Chicago
- Baton Rouge - New Orleans
- Bus from Albany to New York City
- Bus Los Angeles - San Francisco
- Miami - Orlando
- Bus from Los Angeles to San Diego
- Bus Las Vegas - Los Angeles
- Atlanta - Savannah