How much is the bus ticket from Indianapolis to St. Louis?

The cheapest bus tickets from Indianapolis to St. Louis start from $46. The average price for this route is around $62. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Indianapolis to St. Louis?

The average bus travel time from Indianapolis to St. Louis is 4h 20m, covering a distance of 371 km. The quickest bus can get you there in 3h 55m and is operated by Greyhound .

Which bus companies service the Indianapolis to St. Louis route?

Several major bus companies operate on this route with 3 buses available per day, including services from Greyhound , FlixBus , Amtrak , Burlington Trailways .

What are the earliest and latest departure times for the bus from Indianapolis to St. Louis?

The earliest bus departs from Indianapolis to St. Louis at 3:15am. And the latest bus departs at 8:05pm.

What are the CO₂ emissions for the bus trip from Indianapolis to St. Louis?

A bus trip from Indianapolis to St. Louis generates an estimated 9 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.

What is the best bus company from Indianapolis to St. Louis?

According to Busbud customers, the highest-rated bus company on this route is Burlington Trailways , with an average rating of 4.2 out of 5 stars based on 20 reviews.

Which bus company has the best Wi-Fi from Indianapolis to St. Louis?

Based on Busbud reviews, the bus company Burlington Trailways has the highest Wi-Fi rating with a score of 5.0.

Which bus company has the best on-time performance from Indianapolis to St. Louis?

According to Busbud traveller reviews, the most punctual bus company on this route is Burlington Trailways , with a punctuality rating of 5.0 out of 5 stars.

Which bus company has the cleanest buses from Indianapolis to St. Louis?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Burlington Trailways , with a cleanliness rating of 5.0 out of 5 stars.

Bus Indianapolis to St. Louis from $36 | Refundable Tickets

Next departures

Next departures for Indianapolis to St. Louis on December 26
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
11:25am	Indianapolis Bus Station	4h 55m	3:20pm	Gateway Station	Cheapest
5:00am	Indianapolis Bus Station	3h 55m	7:55am	Gateway Station	Fastest
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags
8:05pm	Indianapolis Bus Station	4h 20m	11:25pm	Gateway Station	No tags
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags

Next departures for Indianapolis to St. Louis on December 27
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
5:00am	Indianapolis Bus Station	3h 55m	7:55am	Gateway Station	CheapestFastest
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags
11:25am	Indianapolis Bus Station	4h 55m	3:20pm	Gateway Station	No tags
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags
8:05pm	Indianapolis Bus Station	4h 20m	11:25pm	Gateway Station	No tags

Next departures for Indianapolis to St. Louis on December 28
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
5:00am	Indianapolis Bus Station	3h 55m	7:55am	Gateway Station	CheapestFastest
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags
11:25am	Indianapolis Bus Station	4h 55m	3:20pm	Gateway Station	No tags
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags
8:05pm	Indianapolis Bus Station	4h 20m	11:25pm	Gateway Station	No tags

Next departures for Indianapolis to St. Louis on December 29
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
11:25am	Indianapolis Bus Station	4h 55m	3:20pm	Gateway Station	Cheapest
5:00am	Indianapolis Bus Station	3h 55m	7:55am	Gateway Station	Fastest
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags
8:05pm	Indianapolis Bus Station	4h 20m	11:25pm	Gateway Station	No tags
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags

Next departures for Indianapolis to St. Louis on December 30
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
8:05pm	Indianapolis Bus Station	4h 20m	11:25pm	Gateway Station	Cheapest
5:00am	Indianapolis Bus Station	3h 55m	7:55am	Gateway Station	Fastest
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags
11:25am	Indianapolis Bus Station	4h 55m	3:20pm	Gateway Station	No tags
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags

Next departures for Indianapolis to St. Louis on December 31
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
11:25am	Indianapolis Bus Station	4h 55m	3:20pm	Gateway Station	Cheapest
5:00am	Indianapolis Bus Station	3h 55m	7:55am	Gateway Station	Fastest
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags
8:05pm	Indianapolis Bus Station	4h 20m	11:25pm	Gateway Station	No tags
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags

Last refresh of the prices: Yesterday at 11:44 AM EST.

Compare 2 ways to go from Indianapolis to St. Louis

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach St. Louis. The journey takes about 4 hours 20 minutes, and with fares starting at just $46, it presents an excellent value for a comfortable ride.

3bus per day

4h 20mAverage Duration

371 kmDistance

9kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$46 - $190	Average Duration4h 20m	CO₂ emissions 9kg CO₂e
Train	Average Price$91 - $944	Average Duration14h 25m	CO₂ emissions 34kg CO₂e

Where are the popular stops in Indianapolis and St. Louis?

Stops in Indianapolis

A
Greyhound Amtrak Station
350 S Illinois St, Indianapolis, IN 46225
Visit page

Stops in St. Louis

A
Gateway Station
430 S 15th St, St Louis, MO 63103
Visit page

Compare bus companies

Greyhound

3.5/587,451 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Based on 87451 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $46

Greyhound Indianapolis St. Louis recent customer reviews

The bus had some problems. Air conditioning was malfunctioning, and none of the outlets worked. There was also considerable damage to the seats that should have been repaired. The counter clerk was very friendly and helpful, but the bus driver seemed to be in a very bad mood and possibly ill, loudly coughing up phlegm the entire trip, and he gave us no indication of how late the bus was going to arrive. I will not ride Greyhound again if I can possibly avoid it.

Tremain X.

September 25, 2019

The 3:15 bus never arrived so I was forced to wait 6 hours at the station for the next departure. This was very poorly communicated to passengers and no effort was made for any sort of reimbursement. I will absolutely never use Greyhound again.

Matthew N.

August 16, 2018

FlixBus

3.5/511,738 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wifi2.7

Amtrak

4/55,676 reviews

Staff4.7

Timeliness3.8

Cleanliness4.6

Wifi3.6

Burlington Trailways

4/520 reviews

Staff5

Timeliness5

Cleanliness5

Wifi5

US Bus Companies: FlixBus, BlaBlaCar Bus, Greyhound, ALSA, Intercape, Trenitalia, Big Sky

Frequently asked questions about travelling from Indianapolis to St. Louis by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Indianapolis to St. Louis?
The cheapest bus tickets from Indianapolis to St. Louis start from $46. The average price for this route is around $62. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Indianapolis to St. Louis?
The average bus travel time from Indianapolis to St. Louis is 4h 20m, covering a distance of 371 km. The quickest bus can get you there in 3h 55m and is operated by Greyhound.
Which bus companies service the Indianapolis to St. Louis route?
Several major bus companies operate on this route with 3 buses available per day, including services from Greyhound, FlixBus, Amtrak, Burlington Trailways.
What are the earliest and latest departure times for the bus from Indianapolis to St. Louis?
The earliest bus departs from Indianapolis to St. Louis at 3:15am. And the latest bus departs at 8:05pm.
What are the CO₂ emissions for the bus trip from Indianapolis to St. Louis?
A bus trip from Indianapolis to St. Louis generates an estimated 9 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Indianapolis to St. Louis?
According to Busbud customers, the highest-rated bus company on this route is Burlington Trailways, with an average rating of 4.2 out of 5 stars based on 20 reviews.
Which bus company has the best Wi-Fi from Indianapolis to St. Louis?
Based on Busbud reviews, the bus company Burlington Trailways has the highest Wi-Fi rating with a score of 5.0.
Which bus company has the best on-time performance from Indianapolis to St. Louis?
According to Busbud traveller reviews, the most punctual bus company on this route is Burlington Trailways, with a punctuality rating of 5.0 out of 5 stars.
Which bus company has the cleanest buses from Indianapolis to St. Louis?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Burlington Trailways, with a cleanliness rating of 5.0 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

12-23

$82

12-24

$85

Today

$72

12-26

$72

12-27

$68

12-28

$66

12-29

$65

12-30

$61

The cheapest trip from Indianapolis to St. Louis was searched and found on Dec 30, 2025 with a price of $61

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to St. Louis, as early as possible.

You can expect to pay from $61 to $242 for a bus ticket from Indianapolis to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $61 which is on 2025-12-30.

Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.