Bus Tickets from Greenville, SC to Harrisburg

Next departures

Next departures for Greenville to Harrisburg on September 26
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
1116 Woodruff Rd
Harrisburg Bus StationCheapest
FlixBus + Greyhound Lines, Inc.
1116 Woodruff Rd
Harrisburg Bus StationFastest
FlixBus + Greyhound Lines, Inc.
1116 Woodruff Rd
HarrisburgNo tags
FlixBus
1116 Woodruff Rd
HarrisburgNo tags

Accepted payments

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Compare 2 ways to go from Greenville to Harrisburg.

Bus
Average Price$88 - $241Average Duration22h 20m
19kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average Price$187 - $187Average Duration16h 19m
70kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from Greenville to Harrisburg

Among the sustainable travel choices, the train stands out as the good way to reach Harrisburg. The journey takes about 16 hours 19 minutes and with fares starting at just $187, it presents an excellent value for a comfortable ride.

1train per day
16h 19mAverage Duration
$187Cheapest ticket
70kgCO₂ emissions

Bus Greenville, SC to Harrisburg: Trip Overview

Average ticket price$111
Average bus trip duration22h 20m
Number of daily buses4
Earliest bus departure10:50am
Distance478 miles (770 km)
Latest bus departure10:00pm

Greenville to Harrisburg Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Greenville to Harrisburg.

We make it our job to connect you with the most dependable bus companies that cover bus service from Greenville to Harrisburg.

Whether it is cheap bus tickets or more luxurious buses going to Harrisburg from Greenville, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Greenville, SC - Harrisburg

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09/20
No data
09/21
No data
Today
No data
09/23
No data
09/24
$105
09/25
No data
09/26
$129
09/27
No data
busbud logoThe cheapest trip from Greenville, SC to Harrisburg was searched and found on Sep 24, 2025 with a price of $105

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Harrisburg, as early as possible.

You can expect to pay from $105 to $129 for a bus ticket from Greenville, SC to Harrisburg based on the last 2 days. You can expect to find the cheapest price for the trip at $105 which is on 2025-09-24.

Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Greenville to Harrisburg but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Greenville to Harrisburg.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Greenville to Harrisburg.

Make a music playlist for your bus ride from Greenville to Harrisburg, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

What's the cheapest way to go from Greenville, SC to Harrisburg?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Greenville, SC by bus?

Bus from Harrisburg to Greenville, SC

You can also go to Harrisburg by train

Train from Greenville, SC to Harrisburg

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

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