Bus Tickets from Harrisburg to Greenville, SC

Previously seen trips

Next departures for Harrisburg to Greenville on September 19
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound
Harrisburg Bus Station
1116 Woodruff RdNo tags
Greyhound + FlixBus
Harrisburg Bus Station
1116 Woodruff RdNo tags
Greyhound + FlixBus
Harrisburg Bus Station
1116 Woodruff RdNo tags
FlixBus + Greyhound
Harrisburg Bus Station
1116 Woodruff RdNo tags
Greyhound + FlixBus
Harrisburg Bus Station
1116 Woodruff RdNo tags

Accepted payments

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  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from Harrisburg to Greenville.

Bus
Average Price$63 - $213Average Duration22h 15m
19kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average Price$164 - $235Average Duration16h 19m
70kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from Harrisburg to Greenville

Among the sustainable travel choices, the train stands out as the good way to reach Greenville. The journey takes about 16 hours 19 minutes and with fares starting at just $164, it presents an excellent value for a comfortable ride.

1train per day
16h 19mAverage Duration
$164Cheapest ticket
70kgCO₂ emissions

Bus Harrisburg to Greenville, SC: Trip Overview

Average ticket price$103
Average bus trip duration22h 15m
Number of daily buses6
Earliest bus departure3:05am
Distance478 miles (770 km)
Latest bus departure11:20pm

Harrisburg to Greenville Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Harrisburg to Greenville.

We make sure you can find a bus service from Harrisburg to Greenville from the most reliable bus companies operating this trip.

Discover how much the bus trip from Harrisburg to Greenville will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip Harrisburg - Greenville, SC

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09/17
$61
09/18
No data
Today
No data
09/20
No data
09/21
No data
09/22
No data
09/23
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09/24
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busbud logoThe cheapest trip from Harrisburg to Greenville, SC was searched and found on Sep 17, 2025 with a price of $61

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Harrisburg to Greenville, SC, as early as possible.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Harrisburg to Greenville but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Harrisburg to Greenville, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Harrisburg to Greenville will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Harrisburg to Greenville.

Did you know?

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

What's the cheapest way to go from Harrisburg to Greenville, SC?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Harrisburg by bus?

Bus from Greenville, SC to Harrisburg

You can also go to Greenville, SC by train

Train from Harrisburg to Greenville, SC

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