Bus Tickets from Greenville, SC to Harrisburg

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TodayAug 1
from US$105
TomorrowAug 2
SunAug 3
MonAug 4
TueAug 5
WedAug 6
ThuAug 7
FriAug 8

Cheap buses leaving today

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: August 1 at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: August 2 at
    Destination city: Harrisburg
    Destination location: Harrisburg
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: August 1 at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: August 2 at
    Destination city: Harrisburg
    Destination location: Harrisburg Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 1 at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: August 2 at
    Destination city: Harrisburg
    Destination location: Harrisburg Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: August 1 at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: August 2 at
    Destination city: Harrisburg
    Destination location: Harrisburg
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: August 1 at
    Departure city: Greenville
    Departure location: 1116 Woodruff Rd
    Arrival time: August 2 at
    Destination city: Harrisburg
    Destination location: Harrisburg Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

Last refresh of the prices: 2025-07-25 EDT.

Prices and availability are subject to change.

Accepted payments

  • Visa
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  • American Express
  • China Union Pay
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  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from Greenville to Harrisburg

Bus
Average PriceUS$90 - US$275Average Duration1d
19kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average PriceUS$187 - US$187Average Duration16h 19m
70kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the bus from Greenville to Harrisburg

Among the sustainable travel choices, the bus stands out as a good way to reach Harrisburg. The journey takes about 1 day, and with fares starting at just US$90, it presents an excellent value for a comfortable ride.

4bus per day
1d Average Duration
US$90Cheapest ticket
19kgCO₂ emissions

Bus Greenville, SC to Harrisburg: Trip Overview

Average Ticket PriceUS$124
Average Bus Trip Duration1d
Number of daily buses4
Earliest bus departure10:50am
Distance770 km
Latest bus departure10:00pm

Greenville to Harrisburg Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Greenville to Harrisburg.

We make it our job to connect you with the most dependable bus companies that cover bus service from Greenville to Harrisburg.

Whether it is cheap bus tickets or more luxurious buses going to Harrisburg from Greenville, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Greenville, SC - Harrisburg

  1. What is the distance between Greenville and Harrisburg?

    It's about 775 km (481 miles) from Greenville to Harrisburg.

  2. What are the departure and arrival locations for buses traveling from Greenville to Harrisburg?

    Buses departing from Guadalajara Supermarket Bus Stop in Greenville will take you to Harrisburg Bieber Greyhound Station in Harrisburg.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
07-30
No data
07-31
No data
Today
US$116
08-02
No data
08-03
US$89
08-04
US$103
08-05
No data
08-06
No data
busbud logoThe cheapest trip from Greenville, SC to Harrisburg was searched and found on Aug 3, 2025 with a price of US$89

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Harrisburg, as early as possible.

You can expect to pay from US$89 to US$116 for a bus ticket from Greenville, SC to Harrisburg based on the last 2 days. You can expect to find the cheapest price for the trip at US$89 which is on 2025-08-03.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Greenville to Harrisburg but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Greenville to Harrisburg.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Greenville to Harrisburg.

Make a music playlist for your bus ride from Greenville to Harrisburg, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

What's the cheapest way to go from Greenville, SC to Harrisburg?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Greenville, SC by bus?

Bus from Greenville, SC to Harrisburg

You can also go to Harrisburg by train

Train from Greenville, SC to Harrisburg

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

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