Bus Tickets from Orlando to Greenville, SC

Next departures

Next departures for Orlando to Greenville on September 2
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
The Florida Mall
1116 Woodruff RdCheapest
Greyhound Lines, Inc.
Orlando Bus Station
1116 Woodruff RdFastest
Greyhound Lines, Inc.
Orlando Bus Station
1116 Woodruff RdNo tags
FlixBus + Greyhound Lines, Inc.
Orlando Bus Station
1116 Woodruff RdNo tags

Accepted payments

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Compare 2 ways to go from Orlando to Greenville

Bus
Average PriceUS$65 - US$152Average Duration11h 55m
18kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average PriceUS$129 - US$621Average Duration1d 10h
65kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Orlando to Greenville

Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 11 hours 55 minutes, and with fares starting at just US$65, it presents an excellent value for a comfortable ride.

5bus per day
11h 55mAverage Duration
US$65Cheapest ticket
18kgCO₂ emissions

Bus Orlando to Greenville, SC: Trip Overview

Average Ticket PriceUS$88
Average Bus Trip Duration11h 55m
Number of daily buses5
Earliest bus departure5:15am
Distance704 km
Latest bus departure10:55pm

Orlando to Greenville Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Orlando to Greenville.

We make sure you can find a bus service from Orlando to Greenville from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses travelling from Orlando to Greenville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Orlando - Greenville, SC

  1. What is the distance between Orlando and Greenville?

    Orlando and Greenville are 710 km (440 miles) apart.

  2. What are the departure and arrival locations for buses traveling from Orlando to Greenville?

    Buses departing from Orlando Bus Station in Orlando will take you to Guadalajara Supermarket Bus Stop in Greenville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-31
US$84
09-01
US$144
Today
US$75
09-03
No data
09-04
US$84
09-05
US$78
09-06
No data
09-07
No data
busbud logoThe cheapest trip from Orlando to Greenville, SC was searched and found on Sep 2, 2025 with a price of US$75

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Orlando to Greenville, SC, as early as possible.

You can expect to pay from US$75 to US$144 for a bus ticket from Orlando to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at US$78 which is on 2025-09-05.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Orlando to Greenville but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Orlando to Greenville, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Orlando to Greenville that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Orlando to Greenville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

What's the cheapest way to go from Orlando to Greenville, SC?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Orlando by bus?

Bus from Greenville, SC to Orlando

You can also go to Greenville, SC by train

Train from Orlando to Greenville, SC

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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