What is the distance between Greenville and Fort Myers?

The distance separating Greenville and Fort Myers is 570 miles (918 km).

What are the departure and arrival stations when taking the bus from Greenville to Fort Myers?

If you're headed to Fort Myers from Greenville, chances are that your bus will leave from Guadalajara Supermarket Bus Stop and arrive at Daniels Pkwy & I-75. These are the main departure and arrival locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.

What are the best sights and things to do in Fort Myers?

Once in Fort Myers, you can start exploring the city and discover its surroundings. The top sights and things to do are Edison and Ford Winter Estates, Centennial Park, Burroughs Home & Garden, Calusa Nature Center and Planetarium and Nature Parks.

Bus Greenville to Fort Myers from $81 | Refundable Tickets

Previously seen trips

One passenger / one way

Departure time: January 3 at 3:30pm
Departure city: Greenville
Departure location: 1116 Woodruff Rd
Arrival time: January 4 at 2:25pm
Destination city: Fort Myers
Destination location: Ft Myers Bus Station
Operated by: Greyhound + FlixBus
Greyhound + FlixBus
Vehicle: BusDuration: 22h 55m
Departure time: January 6 at 6:05pm
Departure city: Greenville
Departure location: 1116 Woodruff Rd
Arrival time: January 7 at 1:20pm
Destination city: Fort Myers
Destination location: Fort Myers-Cape Coral
Operated by: Greyhound + FlixBus
Greyhound + FlixBus
Vehicle: BusDuration: 19h 15m
Departure time: January 11 at 7:45pm
Departure city: Greenville
Departure location: 1116 Woodruff Rd
Arrival time: January 12 at 4:05pm
Destination city: Fort Myers
Destination location: Fort Myers-Cape Coral
Operated by: FlixBus + Greyhound
FlixBus + Greyhound
Vehicle: BusDuration: 20h 20m
Departure time: January 15 at 3:30pm
Departure city: Greenville
Departure location: 1116 Woodruff Rd
Arrival time: January 16 at 1:20pm
Destination city: Fort Myers
Destination location: Fort Myers-Cape Coral
Operated by: Greyhound + FlixBus
Greyhound + FlixBus
Vehicle: BusDuration: 21h 50m
Departure time: January 19 at 7:50pm
Departure city: Greenville
Departure location: 1116 Woodruff Rd
Arrival time: January 20 at 4:05pm
Destination city: Fort Myers
Destination location: Fort Myers-Cape Coral
Operated by: Greyhound + FlixBus
Greyhound + FlixBus
Vehicle: BusDuration: 20h 15m

Accepted payments

Compare 2 ways to go from Greenville to Fort Myers.

	Average Price	Average Duration	CO₂ emissions
Bus	Average Price$75 - $198	Average Duration22h	CO₂ emissions 23kg CO₂e5 out of 5 stars	CheapestFastestMost eco-friendly
Train	Average Price$280 - $526	Average Duration1d 14h	CO₂ emissions 83kg CO₂e1 out of 5 stars

Busbud recommends taking the bus from Greenville to Fort Myers

Among the sustainable travel choices, the bus stands out as the good way to reach Fort Myers. The journey takes about 22 hours and with fares starting at just $75, it presents an excellent value for a comfortable ride.

3bus per day

22hAverage Duration

$75Cheapest ticket

23kgCO₂ emissions

Bus Greenville, SC to Fort Myers: Trip Overview

Average ticket price$109

Average bus trip duration22h

Number of daily buses3

Earliest bus departure1:25pm

Distance566 miles (912 km)

Latest bus departure10:00pm

Compare bus companies

FlixBus

3.5/510,378 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

Greyhound

3.5/587,233 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.3

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies: FlixBus, Greyhound, Tornado Bus, Los Limousines, Valley Transit, Tufesa, Wanda Coach

Greenville to Fort Myers Bus

Busbud helps you find a bus from Greenville to Fort Myers. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from Greenville to Fort Myers will be provided by the most trusted bus companies.

Discover how much the bus trip from Greenville to Fort Myers will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Where are the popular stops in Greenville and Fort Myers?

Stops in Greenville

A - Guadalajara Supermarket Bus Stop

B - Greenville Bus Station

Stops in Fort Myers

A - Daniels Pkwy & I-75

B - Colonial Blvd & I-75

C - Rosa Parks

Frequently asked questions for your trip Greenville, SC - Fort Myers

What is the distance between Greenville and Fort Myers?
What are the departure and arrival stations when taking the bus from Greenville to Fort Myers?
What are the best sights and things to do in Fort Myers?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

09/02

No data

09/03

$90

Today

No data

09/05

No data

09/06

No data

09/07

$102

09/08

$85

09/09

No data

The cheapest trip from Greenville, SC to Fort Myers was searched and found on Sep 8, 2025 with a price of $85

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Fort Myers, as early as possible.

You can expect to pay from $85 to $102 for a bus ticket from Greenville, SC to Fort Myers based on the last 2 days. You can expect to find the cheapest price for the trip at $85 which is on 2025-09-08.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Greenville and Fort Myers!

Much more than a mere vehicle taking you from Greenville to Fort Myers, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Greenville to Fort Myers will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Greenville to Fort Myers.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

What's the cheapest way to go from Greenville, SC to Fort Myers?

The bus is the cheapest travel choice for this destination

Vehicle Type	Travel Time	Avg Price	Daily Departures
Vehicle TypeBus	Travel Time22h	Avg Price$109	Daily Departures3
Vehicle TypeTrain	Travel Time1d 14h	Avg Price$280	Daily Departures2

Will you be returning to Greenville, SC by bus?

Bus from Fort Myers to Greenville, SC

Top traveled bus routes

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

Bus Tickets from Greenville, SC to Fort Myers

Previously seen trips

One passenger / one way

Compare 2 ways to go from Greenville to Fort Myers.

Bus Greenville, SC to Fort Myers: Trip Overview

Compare bus companies

Greenville to Fort Myers Bus

Where are the popular stops in Greenville and Fort Myers?

Frequently asked questions for your trip Greenville, SC - Fort Myers

What is the distance between Greenville and Fort Myers?

What are the departure and arrival stations when taking the bus from Greenville to Fort Myers?

What are the best sights and things to do in Fort Myers?

Find cheapest prices for buses

About Bus Travel

Bus Travel Tips

Did you know?

What's the cheapest way to go from Greenville, SC to Fort Myers?

Will you be returning to Greenville, SC by bus?

Top traveled bus routes

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

People from around the world trust Busbud

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