Bus Tickets from Fort Myers to Greenville, SC

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TodaySep 2
from $147
TomorrowSep 3
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Cheap buses leaving today

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: September 2 at
    Departure city: Fort Myers
    Departure location: Ft Myers Bus Station
    Arrival time: September 3 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: September 2 at
    Departure city: Fort Myers
    Departure location: Ft Myers Bus Station
    Arrival time: September 3 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: September 2 at
    Departure city: Fort Myers
    Departure location: Ft Myers Bus Station
    Arrival time: September 3 at
    Destination city: Greenville
    Destination location: 1116 Woodruff Rd
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Bus Fort Myers to Greenville, SC: Trip Overview

Average ticket price$121
Average bus trip duration18h 15m
Number of daily buses2
Earliest bus departure12:20pm
Distance568 miles (916 km)
Latest bus departure6:35pm

Fort Myers to Greenville Bus

With Busbud, comparing and booking tickets for a bus from Fort Myers to Greenville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Fort Myers to Greenville.

From cheap bus tickets to more luxurious buses traveling from Fort Myers to Greenville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip Fort Myers - Greenville, SC

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/31
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09/01
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Today
$209
09/03
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busbud logoThe cheapest trip from Fort Myers to Greenville, SC was searched and found on Sep 2, 2025 with a price of $209

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Fort Myers to Greenville, SC, as early as possible.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Fort Myers to Greenville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Fort Myers to Greenville.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Fort Myers to Greenville that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Fort Myers to Greenville.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Will you be returning to Fort Myers by bus?

Bus from Greenville, SC to Fort Myers

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