Find coaches from Panama City, US to Big Pine Key

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Today2 Sept
Tomorrow3 Sept
from US$142
Thu4 Sept
Fri5 Sept
Sat6 Sept
Sun7 Sept
Mon8 Sept
Tue9 Sept

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: 3 September at
    Departure city: Panama City
    Departure location: Panama City Beach Station
    Arrival time: 4 September at
    Destination city: Big Pine Key
    Destination location: Big Pine Key, FL
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 3 September at
    Departure city: Panama City
    Departure location: Panama City Beach Station
    Arrival time: 4 September at
    Destination city: Big Pine Key
    Destination location: Big Pine Key, FL
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Bus Panama City, US to Big Pine Key: Trip Overview

Average ticket priceUS$138
Average bus trip duration23h 55m
Number of daily buses2
Earliest bus departure07:40
Distance467 miles
Latest bus departure12:50

Panama City to Big Pine Key Bus

Busbud helps you find a bus from Panama City to Big Pine Key. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from Panama City to Big Pine Key from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Big Pine Key from Panama City, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Panama City, US - Big Pine Key

  1. How far is Big Pine Key from Panama City by coach?

    The distance between Panama City and Big Pine Key by coach is approximately 462 miles (745 km).

  2. What is the best way to go from Panama City to Big Pine Key without flying?

    You have the option to select the coach for your journey on this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
31/08
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01/09
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Today
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03/09
US$135
04/09
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05/09
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06/09
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busbud logoThe cheapest trip from Panama City, US to Big Pine Key was searched and found on 3 Sept 2025 with a price of US$135

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Panama City, US to Big Pine Key as early as possible.

You can expect to pay from US$135 to US$136 for a bus ticket from Panama City, US to Big Pine Key based on the last 2 days. You can expect to find the cheapest price for the trip at US$135, which is on 2025-09-03.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Panama City and Big Pine Key!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Panama City to Big Pine Key, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Panama City to Big Pine Key.

Make a music playlist for your bus ride from Panama City to Big Pine Key, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to Panama City, US by bus?

Bus from Big Pine Key to Panama City, US

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