Find coaches from Big Pine Key to Panama City, US

Next departures

Next departures from Big Pine Key to Panama City on 20 September
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.
Big Pine Key, FL
Panama City Beach StationCheapestFastest

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Bus Big Pine Key to Panama City, US: Trip Overview

Average ticket priceUS$146
Average bus trip duration21h
Number of daily buses1
Earliest bus departure17:40
Distance467 miles

Big Pine Key to Panama City Bus

Busbud helps you find a bus from Big Pine Key to Panama City. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Big Pine Key to Panama City.

From cheap bus tickets to more luxurious buses travelling from Big Pine Key to Panama City, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Big Pine Key - Panama City, US

  1. What's the distance between Big Pine Key and Panama City by coach?

    The distance between Big Pine Key and Panama City by coach is approximately 462 miles (745 km).

  2. What is the best way to go from Big Pine Key to Panama City without flying?

    You have the option to select the coach for your journey on this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You also have the option of utilising carpooling services.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
18/09
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19/09
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Today
US$139
21/09
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22/09
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23/09
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24/09
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25/09
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busbud logoThe cheapest trip from Big Pine Key to Panama City, US was searched and found on 20 Sept 2025 with a price of US$139

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Big Pine Key to Panama City, US as early as possible.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Big Pine Key and Panama City!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Big Pine Key to Panama City.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Big Pine Key to Panama City that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from Big Pine Key to Panama City while indulging in miles on end of beautiful scenic views.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Will you be returning to Big Pine Key by bus?

Bus from Panama City, US to Big Pine Key

Why choose Busbud?

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