Find coaches from Florence, SC, US to Harrisburg

Today2 Aug
Tomorrow3 Aug
from US$157
Mon4 Aug
Tue5 Aug
Wed6 Aug
Thu7 Aug
Fri8 Aug
Sat9 Aug

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 3 August at
    Departure city: Florence
    Departure location: Bus station
    Arrival time: 4 August at
    Destination city: Harrisburg
    Destination location: Harrisburg Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 3 August at
    Departure city: Florence
    Departure location: Florence, SC
    Arrival time: 3 August at
    Destination city: Harrisburg
    Destination location: Harrisburg Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: 3 August at
    Departure city: Florence
    Departure location: Bus station
    Arrival time: 4 August at
    Destination city: Harrisburg
    Destination location: Harrisburg
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: 3 August at
    Departure city: Florence
    Departure location: Florence, SC
    Arrival time: 3 August at
    Destination city: Harrisburg
    Destination location: Harrisburg Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Compare 2 ways to travel from Florence to Harrisburg

Bus
Average priceUS$88 - US$301Average duration20h 55m
18kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average priceUS$178 - US$348Average duration14h 54m
66kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from Florence to Harrisburg

Among the sustainable travel choices, the train stands out as a good way to reach Harrisburg. The journey takes about 14 hours 54 minutes and with fares starting at just US$178, it presents an excellent value for a comfortable ride.

1train per day
14h 54mAverage duration
US$178Cheapest ticket
66kgCO₂ emissions

Bus Florence, SC, US to Harrisburg: Trip Overview

Average ticket priceUS$192
Average bus trip duration20h 55m
Number of daily buses2
Earliest bus departure00:05
Distance448 miles
Latest bus departure16:15

Florence to Harrisburg Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Florence to Harrisburg.

We make sure you can find a bus service from Florence to Harrisburg from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Harrisburg from Florence, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Florence, SC, US - Harrisburg

  1. How far is Harrisburg from Florence by coach?

    The journey from Florence to Harrisburg by coach covers an approximate distance of 446 miles (718 km).

  2. What is the best way to go from Florence to Harrisburg without flying?

    You can choose the coach to travel this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
31/07
US$154
01/08
US$147
Today
No data
03/08
US$170
04/08
No data
05/08
No data
06/08
No data
07/08
No data
busbud logoThe cheapest trip from Florence, SC, US to Harrisburg was searched and found on 1 Aug 2025 with a price of US$147

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Florence, SC, US to Harrisburg as early as possible.

You can expect to pay from US$147 to US$170 for a bus ticket from Florence, SC, US to Harrisburg based on the last 2 days. You can expect to find the cheapest price for the trip at US$170, which is on 2025-08-03.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Florence to Harrisburg but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Florence to Harrisburg, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Florence to Harrisburg.

Tune out to the fine sounds of your best music playlist on your bus trip from Florence to Harrisburg while indulging in miles on end of beautiful scenic views.

Did you know?

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

What's the cheapest way to go from Florence, SC, US to Harrisburg?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Florence, SC, US by bus?

Bus from Florence, SC, US to Harrisburg

You can also go to Harrisburg by train

Train from Florence, SC, US to Harrisburg

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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