Find coaches from Baltimore to Florence, SC, US

Find affordable coach tickets from Baltimore to Florence, SC, US with flexible options. Book your journey now

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Thu4 Sept
from US$68
Fri5 Sept
from US$69
Sat6 Sept
Sun7 Sept
Mon8 Sept
from US$62
Tue9 Sept
from US$63
Wed10 Sept
Thu11 Sept

Cheap buses leaving Friday

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 5 September at
    Departure city: Baltimore
    Departure location: Baltimore Downtown Bus Station
    Arrival time: 6 September at
    Destination city: Florence
    Destination location: Bus station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 5 September at
    Departure city: Baltimore
    Departure location: O'Donnell St. & Travel Plaza, Infront of TA Gas station
    Arrival time: 6 September at
    Destination city: Florence
    Destination location: 2301 W Lucas St.
    Operated by: Wanda CoachWanda Coach
    Vehicle: BusDuration:
  • Departure time: 5 September at
    Departure city: Baltimore
    Departure location: O'Donnell St. & Travel Plaza, Infront of TA Gas station
    Arrival time: 6 September at
    Destination city: Florence
    Destination location: 2301 W Lucas St.
    Operated by: Wanda CoachWanda Coach
    Vehicle: BusDuration:
  • Departure time: 5 September at
    Departure city: Baltimore
    Departure location: Baltimore Downtown Bus Station
    Arrival time: 5 September at
    Destination city: Florence
    Destination location: Bus station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: 5 September at
    Departure city: Baltimore
    Departure location: Baltimore Downtown Bus Station
    Arrival time: 6 September at
    Destination city: Florence
    Destination location: Florence, SC
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:

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Compare 2 ways to travel from Baltimore to Florence

Bus
Average priceUS$52 - US$162Average duration10h 50m
16kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average priceUS$83 - US$273Average duration9h 12m
56kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from Baltimore to Florence

Among the sustainable travel choices, the train stands out as a good way to reach Florence. The journey takes about 9 hours 12 minutes and with fares starting at just US$83, it presents an excellent value for a comfortable ride.

3train per day
9h 12mAverage duration
US$83Cheapest ticket
56kgCO₂ emissions

Bus Baltimore to Florence, SC, US: Trip Overview

Average ticket priceUS$84
Average bus trip duration10h 50m
Number of daily buses5
Earliest bus departure01:55
Distance392 miles
Latest bus departure23:45

Baltimore to Florence Bus

Busbud helps you find a bus from Baltimore to Florence. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from Baltimore to Florence will be provided by the most trusted bus companies.

Discover how much the bus trip from Baltimore to Florence will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Baltimore - Florence, SC, US

  1. What's the distance between Baltimore and Florence by coach?

    The distance between Baltimore and Florence by coach is approximately 389 miles (627 km).

  2. What is the best way to go from Baltimore to Florence without flying?

    You can choose the coach to travel this route. The coach ensures a pleasant travel experience, granting you the opportunity to appreciate the scenery as you make your way to your final stop. You also have the option of utilising carpooling services.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
31/08
US$74
01/09
US$100
Today
US$100
03/09
US$89
04/09
US$66
05/09
US$84
06/09
US$77
07/09
US$74
busbud logoThe cheapest trip from Baltimore to Florence, SC, US was searched and found on 4 Sept 2025 with a price of US$66

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Baltimore to Florence, SC, US as early as possible.

You can expect to pay from US$66 to US$121 for a bus ticket from Baltimore to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$66, which is on 2025-09-04.

Usually Wanda Coach will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Baltimore and Florence!

Much more than a mere vehicle taking you from Baltimore to Florence, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Baltimore to Florence will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Baltimore to Florence.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

What's the cheapest way to go from Baltimore to Florence, SC, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Baltimore by bus?

Bus from Florence, SC, US to Baltimore

You can also go to Florence, SC, US by train

Train from Baltimore to Florence, SC, US

Why choose Busbud?

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