Find coaches from Des Moines to Chicago

Next departures

Next departures from Des Moines to Chicago on 15 September
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.
Des Moines (Subway)
Downtown Greyhound StationCheapestFastest
Greyhound Lines, Inc. + FlixBus
Des Moines (Subway)
Chicago 95Th & Dan RyanNo tags

Accepted payments

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Bus Des Moines to Chicago: Trip Overview

Average ticket priceUS$54
Average bus trip duration11h 35m
Number of daily buses3
Earliest bus departure05:30
Distance308 miles
Latest bus departure23:15

Des Moines to Chicago Bus

With Busbud, comparing and booking tickets for a bus from Des Moines to Chicago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Des Moines to Chicago from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses travelling from Des Moines to Chicago, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Des Moines - Chicago

  1. What's the distance between Des Moines and Chicago by coach?

    The journey from Des Moines to Chicago by coach covers an approximate distance of 308 miles (496 km).

  2. What is the best way to go from Des Moines to Chicago without flying?

    To travel from Des Moines to Chicago without flying, you can take the coaches. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You also have the option of utilising carpooling services.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
12/09
US$56
13/09
US$56
Today
US$56
15/09
US$53
16/09
US$47
17/09
US$40
18/09
US$38
19/09
US$40
busbud logoThe cheapest trip from Des Moines to Chicago was searched and found on 18 Sept 2025 with a price of US$38

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Chicago as early as possible.

You can expect to pay from US$38 to US$173 for a bus ticket from Des Moines to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$38, which is on 2025-09-18.

Usually Burlington Trailways will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Des Moines to Chicago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Des Moines to Chicago, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Des Moines to Chicago that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Des Moines to Chicago, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Will you be returning to Des Moines by bus?

Bus from Chicago to Des Moines

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