Cheap buses leaving tomorrow
One passenger / one way
- This trip is recommended because it is the: Cheapest + FastestDeparture time: June 15 atDeparture city: Des MoinesDeparture location: Des Moines (Subway)Arrival time: June 15 atDestination city: ChicagoDestination location: Downtown Greyhound StationOperated by: Greyhound Lines, Inc.
Vehicle: BusDuration:
Last refresh of the prices: Today at 1:38 AM CDT.
Prices and availability are subject to change.
Accepted payments
Bus Des Moines to Chicago: Trip Overview
Compare bus companies
Des Moines to Chicago Bus
With Busbud, comparing and booking tickets for a bus from Des Moines to Chicago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
We make sure you can find a bus service from Des Moines to Chicago from the most reliable bus companies operating this trip.
From cheap bus tickets to more luxurious buses travelling from Des Moines to Chicago, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in Des Moines and Chicago?
Frequently asked questions on the trip Des Moines - Chicago
How long does it take to get to Chicago from Des Moines by bus?
The bus ride from Des Moines to Chicago takes 8h 5m, on average. For the shortest travel time, select the fastest bus available, which will take you to Chicago in about 6h 10m.
What is the distance between Des Moines and Chicago?
Des Moines and Chicago are 496 km (308 miles) apart.
What are the departure and arrival locations for buses traveling from Des Moines to Chicago?
Buses departing from Jefferson/Trailways Depot in Des Moines will take you to Downtown Greyhound Station in Chicago.
What is the cheapest way to get from Des Moines to Chicago?
The least expensive way to go from Des Moines to Chicago would be going by bus. The ticket price for this bus starts at US$48, making this your best choice for this trip.
How much is the bus from Des Moines to Chicago?
The bus from Des Moines to Chicago will cost you US$64, on average.
Is it possible to travel by overnight bus from Des Moines to Chicago?
Yes! If you're heading from Des Moines to Chicago, you'll find buses departing until 11:15pm and arriving the next day.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Des Moines to Chicago was searched and found on Jun 18, 2025 with a price of US$43To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Des Moines to Chicago, as early as possible.
You can expect to pay from US$43 to US$173 for a bus ticket from Des Moines to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$43 which is on 2025-06-18.
Usually Burlington Trailways will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while travelling from Des Moines to Chicago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Des Moines to Chicago, get comfy and count the stars.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Des Moines to Chicago that are otherwise impossible to come by with a plane.
Make a music playlist for your bus ride from Des Moines to Chicago, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.
Top travelled bus routes
Why choose Busbud?
The Best Way To Book Bus and Train Tickets
Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.
People from around the world trust Busbud
Popular Buses Connecting Des Moines
Buses Leaving from Des Moines
- Bus from Des Moines to Iowa City
- Bus Des Moines - Washington
- Des Moines - Omaha
- Bus from Des Moines to Denver
- Bus Des Moines - Cedar Rapids
- Des Moines - Chicago
- Bus from Des Moines to Ames
- Bus Des Moines - Jackson
- Des Moines - Sioux Falls
- Bus from Des Moines to New York
- Bus Des Moines - Baltimore
- Des Moines - Keokuk
- Bus from Des Moines to Springfield
- Bus Des Moines - San Diego
- Des Moines - Madison
Buses Going to Des Moines
- Bus from Washington to Des Moines
- Bus Chicago - Des Moines
- Minneapolis - Des Moines
- Bus from Las Vegas to Des Moines
- Bus Staples - Des Moines
- Iowa City - Des Moines
- Bus from Vermillion to Des Moines
- Bus Saint Paul - Des Moines
- Dallas - Des Moines
- Bus from Latimer to Des Moines
- Bus Mobile - Des Moines
- Eau Claire - Des Moines
- Bus from Kansas City to Des Moines
- Bus Bloomington - Des Moines
- Ithaca - Des Moines