Bus Tickets from Knoxville, TN to Louisville

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Previously seen trips

One passenger / one way

  • Departure time: August 28 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: August 29 at
    Destination city: Louisville
    Destination location: Louisville, KY
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: October 13 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: October 14 at
    Destination city: Louisville
    Destination location: Louisville, KY
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: October 13 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: October 14 at
    Destination city: Louisville
    Destination location: Louisville, KY
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: November 1 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: November 2 at
    Destination city: Louisville
    Destination location: Louisville, KY
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:
  • Departure time: November 1 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: November 2 at
    Destination city: Louisville
    Destination location: Louisville, KY
    Operated by: GreyhoundGreyhound
    Vehicle: BusDuration:

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Bus Knoxville, TN to Louisville: Trip Overview

Average Ticket PriceUS$64
Average Bus Trip Duration7h 15m
Number of daily buses1
Earliest bus departure6:15pm
Distance301 km

Knoxville to Louisville Bus

Busbud helps you find a bus from Knoxville to Louisville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from Knoxville to Louisville from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses travelling from Knoxville to Louisville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Knoxville, TN - Louisville

  1. What is the distance between Knoxville and Louisville?

    The distance between Knoxville and Louisville is around 304 km (188 miles).

  2. What are the departure and arrival locations for buses traveling from Knoxville to Louisville?

    Buses traveling this route start their trip at 100 Kirkwood St, in Knoxville, and end it at Louisville Greyhound Bus Station, in Louisville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08-28
US$56
08-29
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08-31
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busbud logoThe cheapest trip from Knoxville, TN to Louisville was searched and found on Aug 28, 2025 with a price of US$56

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Louisville, as early as possible.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Knoxville and Louisville!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Knoxville to Louisville, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Knoxville to Louisville that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from Knoxville to Louisville while indulging in miles on end of beautiful scenic views.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Will you be returning to Knoxville, TN by bus?

Bus from Louisville to Knoxville, TN

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