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One passenger / one way
- This trip is recommended because it is: CheapestDeparture time: June 29 atDeparture city: SantiagoDeparture location: Terminal SurArrival time: June 29 atDestination city: Santa CruzDestination location: Terminal Santa CruzOperated by: Buses Jet Sur
Vehicle: BusDuration: - This trip is recommended because it is: FastestDeparture time: June 29 atDeparture city: SantiagoDeparture location: Terminal SurArrival time: June 29 atDestination city: Santa CruzDestination location: Terminal Santa CruzOperated by: Andimar
Vehicle: BusDuration: - Departure time: June 29 atDeparture city: SantiagoDeparture location: Terminal SurArrival time: June 29 atDestination city: Santa CruzDestination location: Terminal Santa CruzOperated by: Buses Jet SurVehicle: BusDuration:
- Departure time: June 29 atDeparture city: SantiagoDeparture location: Terminal SurArrival time: June 29 atDestination city: Santa CruzDestination location: Terminal Santa CruzOperated by: Buses TranSantin
Vehicle: BusDuration: - Departure time: June 29 atDeparture city: SantiagoDeparture location: Terminal SurArrival time: June 29 atDestination city: Santa CruzDestination location: Terminal Santa CruzOperated by: AndimarVehicle: BusDuration:
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Bus Santiago to Santa Cruz: Trip Overview
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Santiago to Santa Cruz Bus
With Busbud, comparing and booking tickets for a bus from Santiago to Santa Cruz is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
We make sure you can find a bus service from Santiago to Santa Cruz from the most reliable bus companies operating this trip.
From cheap bus tickets to more luxurious buses traveling from Santiago to Santa Cruz, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in Santiago and Santa Cruz?
Frequently asked questions for your trip Santiago, CL - Santa Cruz, CL
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santiago to Santa Cruz was searched and found on Jun 28, 2025 with a price of $7To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago to Santa Cruz, as early as possible.
You can expect to pay from $7 to $12 for a bus ticket from Santiago to Santa Cruz based on the last 2 days. You can expect to find the cheapest price for the trip at $7 which is on 2025-06-30.
Usually Buses Andimar will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while traveling from Santiago to Santa Cruz.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Santiago to Santa Cruz, get comfy and count the stars.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Santiago to Santa Cruz that are otherwise impossible to come by with a plane.
Tune out to the fine sounds of your best music playlist on your bus trip from Santiago to Santa Cruz while indulging in miles on end of beautiful scenic views.
Did you know?
Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
Top traveled bus routes
Why choose Busbud?
The Best Way To Book Bus and Train Tickets
Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.
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Popular Buses Connecting Santiago
Buses Leaving from Santiago
- Bus from Santiago to Antofagasta
- Bus Santiago - Talca
- Santiago - Chillan
- Bus from Santiago to Valdivia
- Bus Santiago - Mendoza
- Santiago - Los Angeles
- Bus from Santiago to Puerto Varas
- Bus Santiago - Santa Cruz
- Santiago - Casablanca
- Bus from Santiago to San Antonio
- Bus Santiago - Arica
- Santiago - Concon
- Bus from Santiago to Villarrica
- Bus Santiago - La Unión
Buses Going to Santiago
- Bus from Victoria to Santiago
- Bus Valdivia - Santiago
- Castro - Santiago
- Bus from San Felipe to Santiago
- Bus Antofagasta - Santiago
- Vina del Mar - Santiago
- Bus from Pichilemu to Santiago
- Bus La Serena - Santiago
- Puerto Varas - Santiago
- Bus from Temuco to Santiago
- Bus Arica - Santiago
- Santa Cruz - Santiago
- Bus from San Antonio to Santiago
- Bus Chillan - Santiago
- Los Angeles - Santiago
Popular Buses Connecting Santa Cruz
Buses Leaving from Santa Cruz
Buses Going to Santa Cruz
Popular routes in this country
- Bus from Santiago to Valparaiso
- Bus Santiago - Pucon
- Valparaiso - Santiago
- Bus from Puerto Montt to Santiago
- Bus Puerto Montt - Pucon
- Santiago - Pichilemu
- Bus from Calama to Santiago
- Bus Osorno Province - Pucon
- Pucon - Puerto Montt
- Bus from Santiago to Vina del Mar
- Bus Puerto Natales - Estancia Pudeto
- Santiago - La Serena
- Bus from Puerto Varas to Pucon
- Bus Concepción - Santiago
- Santiago - Temuco