Find coaches from Santiago, CL to Santa Cruz, CL

Find affordable coach tickets from Santiago, CL to Santa Cruz, CL with flexible options. Book your journey now

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Today3 Sept
from US$7
Tomorrow4 Sept
from US$7
Fri5 Sept
from US$7
Sat6 Sept
from US$7
Sun7 Sept
from US$7
Mon8 Sept
from US$7
Tue9 Sept
from US$7
Wed10 Sept
from US$7

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 4 September at
    Departure city: Santiago
    Departure location: Terminal Sur
    Arrival time: 4 September at
    Destination city: Santa Cruz
    Destination location: Terminal Santa Cruz
    Operated by: Buses Jet SurBuses Jet Sur
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 4 September at
    Departure city: Santiago
    Departure location: Terminal Sur
    Arrival time: 4 September at
    Destination city: Santa Cruz
    Destination location: Terminal Santa Cruz
    Operated by: AndimarAndimar
    Vehicle: BusDuration:
  • Departure time: 4 September at
    Departure city: Santiago
    Departure location: Terminal Sur
    Arrival time: 4 September at
    Destination city: Santa Cruz
    Destination location: Terminal Santa Cruz
    Operated by: Buses TranSantinBuses TranSantin
    Vehicle: BusDuration:
  • Departure time: 4 September at
    Departure city: Santiago
    Departure location: Terminal Sur
    Arrival time: 4 September at
    Destination city: Santa Cruz
    Destination location: Terminal Santa Cruz
    Operated by: Buses Jet SurBuses Jet Sur
    Vehicle: BusDuration:
  • Departure time: 4 September at
    Departure city: Santiago
    Departure location: Terminal Sur
    Arrival time: 4 September at
    Destination city: Santa Cruz
    Destination location: Terminal Santa Cruz
    Operated by: AndimarAndimar
    Vehicle: BusDuration:

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Bus Santiago, CL to Santa Cruz, CL: Trip Overview

Average ticket priceUS$8
Average bus trip duration3h
Number of daily buses27
Earliest bus departure06:10
Distance91 miles
Latest bus departure20:59

Santiago to Santa Cruz Bus

With Busbud, comparing and booking tickets for a bus from Santiago to Santa Cruz is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Santiago to Santa Cruz from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses travelling from Santiago to Santa Cruz, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Santiago, CL - Santa Cruz, CL

  1. How far is Santa Cruz from Santiago by coach?

    The distance between Santiago and Santa Cruz by coach is approximately 95 miles (153 km).

  2. Is there a way to reach Santa Cruz from Santiago without a car?

    The best way to go from Santiago to Santa Cruz without a car is by coach. They are frequent and reliable, offering a convenient and eco-friendly journey. You can also consider rideshare services depending on your preferences.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
01/09
US$7
02/09
US$7
Today
US$7
04/09
US$7
05/09
US$7
06/09
US$7
06/09
US$7
08/09
US$7
busbud logoThe cheapest trip from Santiago, CL to Santa Cruz, CL was searched and found on 3 Sept 2025 with a price of US$7

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago, CL to Santa Cruz, CL as early as possible.

You can expect to pay from US$7 to US$11 for a bus ticket from Santiago, CL to Santa Cruz, CL based on the last 2 days. You can expect to find the cheapest price for the trip at US$7, which is on 2025-09-04.

Usually Buses Andimar, buses TranSantin will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Santiago to Santa Cruz.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Santiago to Santa Cruz, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Santiago to Santa Cruz that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from Santiago to Santa Cruz while indulging in miles on end of beautiful scenic views.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Will you be returning to Santiago, CL by bus?

Bus from Santa Cruz, CL to Santiago, CL

Why choose Busbud?

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Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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