Find coaches from La Serena, CL to Santiago, CL

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Today1 Jun
from US$12
Tomorrow2 Jun
from US$9
Tue3 Jun
from US$9
Wed4 Jun
from US$9
Thu5 Jun
from US$9
Fri6 Jun
from US$9
Sat7 Jun
from US$9
Sun8 Jun

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 2 June at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: 2 June at
    Destination city: Santiago
    Destination location: Terminal de Buses San Borja - San Francisco de Borja
    Operated by: Buses RomaniBuses Romani
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 2 June at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: 2 June at
    Destination city: Santiago
    Destination location: Terminal de Buses San Borja - San Francisco de Borja
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • Departure time: 2 June at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: 2 June at
    Destination city: Santiago
    Destination location: Terminal de Buses San Borja - San Francisco de Borja
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • Departure time: 2 June at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: 2 June at
    Destination city: Santiago
    Destination location: Terminal de Buses San Borja
    Operated by: AndimarAndimar
    Vehicle: BusDuration:
  • Departure time: 2 June at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: 2 June at
    Destination city: Santiago
    Destination location: San Borja
    Operated by: Pluss ChilePluss Chile
    Vehicle: BusDuration:

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Bus La Serena to Santiago: Trip Overview

Average ticket priceUS$14
Average bus trip duration6h 10m
Number of daily buses61
Earliest bus departure00:05
Distance241 miles
Latest bus departure23:59

La Serena to Santiago Bus

With Busbud, comparing and booking tickets for a bus from La Serena to Santiago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from La Serena to Santiago will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from La Serena to Santiago, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip La Serena, CL - Santiago, CL

  1. How much is the cheapest coach ticket from La Serena to Santiago?

    For coach travel from La Serena to Santiago, ticket prices typically start at US$9 and can reach a maximum of US$141. The exact cost can vary based on different factors such as the time of travel, the day of the week, and the coach service provider. Use Busbud to compare prices and amenities offered by different companies, ensuring you find the most favorable deals and promotions.

  2. How long does it take to travel from La Serena to Santiago by bus?

    The average duration for a trip from La Serena to Santiago by coach is around 6h 10m. If you're looking for the fastest trip, you can get there in just about 5h 10m. Please be aware that the time it takes for your journey may vary depending on the traffic conditions along the route.

  3. When is the first coach from La Serena to Santiago?

    The first coach to Santiago from La Serena departs at 00:05. Times and services may vary during weekends and holidays.

  4. How far is Santiago from La Serena by coach?

    The distance between La Serena and Santiago by coach is approximately 247 miles (398 km).

  5. Is there a way to reach Santiago from La Serena without a car?

    The best way to go from La Serena to Santiago without a car is by coach. They are frequent and reliable, offering a convenient and eco-friendly journey. You can also consider rideshare services depending on your preferences.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
30/05
US$13
31/05
US$14
Today
US$11
02/06
US$9
03/06
US$9
04/06
US$8
05/06
US$8
06/06
US$9
busbud logoThe cheapest trip from La Serena to Santiago was searched and found on 4 Jun 2025 with a price of US$8

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Serena to Santiago as early as possible.

You can expect to pay from US$8 to US$27 for a bus ticket from La Serena to Santiago based on the last 2 days. You can expect to find the cheapest price for the trip at US$8, which is on 2025-06-04.

Usually PlussChile, Pullman San Andrés will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from La Serena to Santiago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from La Serena to Santiago, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from La Serena to Santiago that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from La Serena to Santiago, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Will you be returning to La Serena by bus?

Bus from La Serena to Santiago

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