Find coaches from Antofagasta to Santiago, CL

Find affordable coach tickets from Antofagasta to Santiago, CL with flexible options. Book your journey now

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Today21 Jun
from US$37
Tomorrow22 Jun
from US$42
Mon23 Jun
from US$38
Tue24 Jun
from US$45
Wed25 Jun
from US$30
Thu26 Jun
from US$45
Fri27 Jun
from US$30
Sat28 Jun
from US$30

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 22 June at
    Departure city: Antofagasta
    Departure location: Terminal Carlos Oviedo Cavada
    Arrival time: 22 June at
    Destination city: Santiago
    Destination location: San Borja
    Operated by: Pullman San AndrésPullman San Andrés
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 22 June at
    Departure city: Antofagasta
    Departure location: Terminal Carlos Oviedo Cavada
    Arrival time: 22 June at
    Destination city: Santiago
    Destination location: San Borja
    Operated by: Pullman San AndrésPullman San Andrés
    Vehicle: BusDuration:
  • Departure time: 22 June at
    Departure city: Antofagasta
    Departure location: Terminal Carlos Oviedo Cavada
    Arrival time: 22 June at
    Destination city: Santiago
    Destination location: San Borja
    Operated by: Pullman San AndrésPullman San Andrés
    Vehicle: BusDuration:
  • Departure time: 22 June at
    Departure city: Antofagasta
    Departure location: Terminal Carlos Oviedo Cavada
    Arrival time: 22 June at
    Destination city: Santiago
    Destination location: San Borja
    Operated by: Pullman San AndrésPullman San Andrés
    Vehicle: BusDuration:
  • Departure time: 22 June at
    Departure city: Antofagasta
    Departure location: Terminal Carlos Oviedo Cavada
    Arrival time: 22 June at
    Destination city: Santiago
    Destination location: San Borja
    Operated by: Pullman San AndrésPullman San Andrés
    Vehicle: BusDuration:

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Bus Antofagasta to Santiago: Trip Overview

Average ticket priceUS$48
Average bus trip duration18h 15m
Number of daily buses33.5945945945946
Earliest bus departure00:15
Distance679 miles
Latest bus departure23:50

Antofagasta to Santiago Bus

With Busbud, comparing and booking tickets for a bus from Antofagasta to Santiago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Antofagasta to Santiago will be provided by the most trusted bus companies.

Discover how much the bus trip from Antofagasta to Santiago will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Antofagasta - Santiago, CL

  1. What's the distance between Antofagasta and Santiago by coach?

    The distance between Antofagasta and Santiago by coach is approximately 677 miles (1091 km).

  2. What is the best way to go from Antofagasta to Santiago without flying?

    You have the option to select the coach for your journey on this route. The coach ensures a pleasant travel experience, granting you the opportunity to appreciate the scenery as you make your way to your final stop. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
19/06
US$35
20/06
US$35
Today
US$35
22/06
US$39
23/06
US$35
24/06
US$41
25/06
US$28
26/06
US$41
busbud logoThe cheapest trip from Antofagasta to Santiago was searched and found on 25 Jun 2025 with a price of US$28

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Antofagasta to Santiago as early as possible.

You can expect to pay from US$28 to US$55 for a bus ticket from Antofagasta to Santiago based on the last 2 days. You can expect to find the cheapest price for the trip at US$28, which is on 2025-06-25.

Usually Buses Andimar will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Antofagasta to Santiago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Antofagasta to Santiago, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Antofagasta to Santiago will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Make a music playlist for your bus ride from Antofagasta to Santiago, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

Will you be returning to Antofagasta by bus?

Bus from Antofagasta to Santiago

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