Bus Tickets from Antofagasta to Santiago, CL

Find affordable bus tickets from Antofagasta to Santiago, CL with flexible options. Book your trip now

Join 75M+ travelers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every step.
Cancel anytime and receive a 100% refund, no reason needed.
SunJun 22
from US$42
MonJun 23
from US$38
TueJun 24
from US$45
WedJun 25
from US$30
ThuJun 26
from US$45
FriJun 27
from US$30
SatJun 28
SunJun 29

Cheap buses leaving Monday

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: June 23 at
    Departure city: Antofagasta
    Departure location: Terminal Antofagasta
    Arrival time: June 24 at
    Destination city: Santiago
    Destination location: San Borja
    Operated by: Pluss ChilePluss Chile
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: June 23 at
    Departure city: Antofagasta
    Departure location: Terminal Carlos Oviedo Cavada
    Arrival time: June 23 at
    Destination city: Santiago
    Destination location: San Borja
    Operated by: Pullman San AndrésPullman San Andrés
    Vehicle: BusDuration:
  • Departure time: June 23 at
    Departure city: Antofagasta
    Departure location: Terminal Antofagasta
    Arrival time: June 24 at
    Destination city: Santiago
    Destination location: San Borja
    Operated by: Pluss ChilePluss Chile
    Vehicle: BusDuration:
  • Departure time: June 23 at
    Departure city: Antofagasta
    Departure location: Terminal Carlos Oviedo Cavada
    Arrival time: June 23 at
    Destination city: Santiago
    Destination location: San Borja
    Operated by: Pullman San AndrésPullman San Andrés
    Vehicle: BusDuration:
  • Departure time: June 23 at
    Departure city: Antofagasta
    Departure location: Terminal Antofagasta
    Arrival time: June 24 at
    Destination city: Santiago
    Destination location: San Borja
    Operated by: Pluss ChilePluss Chile
    Vehicle: BusDuration:

Last refresh of the prices: Today at 10:02 PM -04.

Prices and availability are subject to change.

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Antofagasta to Santiago: Trip Overview

Average Ticket PriceUS$48
Average Bus Trip Duration18h 15m
Number of daily buses33.5945945945946
Earliest bus departure12:15am
Distance1094 km
Latest bus departure11:50pm

Antofagasta to Santiago Bus

With Busbud, comparing and booking tickets for a bus from Antofagasta to Santiago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from Antofagasta to Santiago will be provided by the most trusted bus companies.

Discover how much the bus trip from Antofagasta to Santiago will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Antofagasta - Santiago, CL

  1. What is the distance between Antofagasta and Santiago?

    The distance covered from Antofagasta to Santiago is 1091 km (677 miles).

  2. What are the departure and arrival locations for buses traveling from Antofagasta to Santiago?

    Buses traveling this route start their trip at Terminal Antofagasta, in Antofagasta, and end it at San Borja, in Santiago.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06-18
US$32
06-19
US$35
Today
US$35
06-21
US$35
06-22
US$39
06-23
US$35
06-24
US$41
06-25
US$28
busbud logoThe cheapest trip from Antofagasta to Santiago was searched and found on Jun 25, 2025 with a price of US$28

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Antofagasta to Santiago, as early as possible.

You can expect to pay from US$28 to US$64 for a bus ticket from Antofagasta to Santiago based on the last 2 days. You can expect to find the cheapest price for the trip at US$28 which is on 2025-06-25.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Antofagasta to Santiago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from Antofagasta to Santiago, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Antofagasta to Santiago will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from Antofagasta to Santiago, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

Will you be returning to Antofagasta by bus?

Bus from Antofagasta to Santiago

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

People from around the world trust Busbud

‌

Popular Buses Connecting Antofagasta

Buses Leaving from Antofagasta

Buses Going to Antofagasta

Popular Buses Connecting Santiago

Buses Leaving from Santiago

Buses Going to Santiago