Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Terminal Antofagasta | San Borja | Cheapest | |||||
| Terminal Antofagasta | San Borja | Fastest | |||||
| Terminal Antofagasta | San Borja | No tags | |||||
Pullman San Andrés + Pluss Chile | Terminal Carlos Oviedo Cavada | San Borja | No tags | |||||
| Terminal Antofagasta | San Borja | No tags |
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Bus Antofagasta to Santiago, CL: Trip Overview
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Antofagasta to Santiago Bus
With Busbud, comparing and booking tickets for a bus from Antofagasta to Santiago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
Bus service from Antofagasta to Santiago will be provided by the most trusted bus companies.
Discover how much the bus trip from Antofagasta to Santiago will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.
Where are the popular stops in Antofagasta and Santiago?
Frequently asked questions on the trip Antofagasta - Santiago, CL
What is the distance between Antofagasta and Santiago?
The distance covered from Antofagasta to Santiago is 1091 km (677 miles).
What are the departure and arrival locations for buses traveling from Antofagasta to Santiago?
Buses traveling this route start their trip at Av. Pedro Aguirre Cerda, 253, in Antofagasta, and end it at San Borja, in Santiago.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Antofagasta to Santiago, CL was searched and found on Sep 23, 2025 with a price of US$25To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Antofagasta to Santiago, CL, as early as possible.
You can expect to pay from US$25 to US$78 for a bus ticket from Antofagasta to Santiago, CL based on the last 2 days. You can expect to find the cheapest price for the trip at US$25 which is on 2025-09-23.
Usually Pluss Chile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while travelling from Antofagasta to Santiago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Much more than a mere vehicle taking you from Antofagasta to Santiago, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.
Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Antofagasta to Santiago will emit less CO2 than a car or an airplane.
Make a music playlist for your bus ride from Antofagasta to Santiago, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.
Top travelled bus routes
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Popular Buses Connecting Antofagasta
Buses Leaving from Antofagasta
- Bus from Antofagasta to Santiago
- Bus Antofagasta - Sierra Gorda
- Antofagasta - Coquimbo
- Bus from Antofagasta to Tocopilla
- Bus Antofagasta - Iquique
- Antofagasta - Vallenar
- Bus from Antofagasta to Caldera
- Bus Antofagasta - Calama
- Antofagasta - La Serena
- Bus from Antofagasta to Arica Province
- Bus Antofagasta - Baquedano
- Antofagasta - Pozo Almonte
- Bus from Antofagasta to La Calera
- Bus Antofagasta - Copiapo
- Antofagasta - Taltal
Buses Going to Antofagasta
- Bus from Iquique to Antofagasta
- Bus Santiago - Antofagasta
- Tocopilla - Antofagasta
- Bus from Sierra Gorda to Antofagasta
- Bus Taltal - Antofagasta
- Calama - Antofagasta
- Bus from Vallenar to Antofagasta
- Bus Caldera - Antofagasta
- La Serena - Antofagasta
- Bus from Arica Province to Antofagasta
- Bus Copiapo - Antofagasta
- Coquimbo - Antofagasta
- Bus from Pozo Almonte to Antofagasta
- Bus Ovalle - Antofagasta
- Alto Hospicio - Antofagasta
Popular Buses Connecting Santiago
Buses Leaving from Santiago
- Bus from Santiago to Antofagasta
- Bus Santiago - Mendoza
- Santiago - La Serena
- Bus from Santiago to Valdivia
- Bus Santiago - Talca
- Santiago - Chillan
- Bus from Santiago to Coquimbo
- Bus Santiago - Pichilemu
- Santiago - San Antonio
- Bus from Santiago to Iquique
- Bus Santiago - Caldera
- Santiago - Copiapo
- Bus from Santiago to Los Andes
- Bus Santiago - Puerto Varas
- Santiago - Santa Cruz
Buses Going to Santiago
- Bus from Victoria to Santiago
- Bus Concepción - Santiago
- Castro - Santiago
- Bus from San Felipe to Santiago
- Bus Antofagasta - Santiago
- La Serena - Santiago
- Bus from Coquimbo to Santiago
- Bus Pichilemu - Santiago
- Puerto Montt - Santiago
- Bus from Vina del Mar to Santiago
- Bus Iquique - Santiago
- Temuco - Santiago
- Bus from Caldera to Santiago
- Bus San Pedro de la Paz - Santiago
- Parral - Santiago
Popular routes in this country
- Bus from Castro to Ancud
- Bus Puerto Varas - Castro
- Santiago - Valparaiso
- Bus from Santiago to Pucon
- Bus Calama - Santiago
- Santiago - Vina del Mar
- Bus from Puerto Montt to Pucon
- Bus Puerto Natales - Estancia Pudeto
- Calama - Arica Province
- Bus from Temuco to Pucon
- Bus Ancud - Puerto Montt
- Santiago - Temuco
- Bus from Pucon to Santiago
- Bus Valdivia - Santiago
- San Antonio - Santiago