Bus Tickets from Antofagasta to La Serena, CL

Find affordable bus tickets from Antofagasta to La Serena, CL with flexible options. Book your trip now

Join 75M+ travelers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every step.
Cancel anytime and receive a 100% refund, no reason needed.
TodayJul 25
from US$21
TomorrowJul 26
from US$28
SunJul 27
from US$36
MonJul 28
from US$30
TueJul 29
from US$21
WedJul 30
from US$42
ThuJul 31
from US$30
FriAug 1
from US$21

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: July 26 at
    Departure city: Antofagasta
    Departure location: Terminal Antofagasta
    Arrival time: July 27 at
    Destination city: La Serena
    Destination location: Terminal de Buses La Serena
    Operated by: Pluss ChilePluss Chile
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: July 26 at
    Departure city: Antofagasta
    Departure location: Terminal Antofagasta
    Arrival time: July 26 at
    Destination city: La Serena
    Destination location: Terminal de Buses La Serena
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • Departure time: July 26 at
    Departure city: Antofagasta
    Departure location: Terminal Antofagasta
    Arrival time: July 27 at
    Destination city: La Serena
    Destination location: Terminal de Buses La Serena
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • Departure time: July 26 at
    Departure city: Antofagasta
    Departure location: Terminal Antofagasta
    Arrival time: July 26 at
    Destination city: La Serena
    Destination location: Terminal de Buses La Serena
    Operated by: Pluss ChilePluss Chile
    Vehicle: BusDuration:
  • Departure time: July 26 at
    Departure city: Antofagasta
    Departure location: 5791 Avenida Iquique
    Arrival time: July 27 at
    Destination city: La Serena
    Destination location: Terminal de Buses La Serena
    Operated by: AndimarAndimar
    Vehicle: BusDuration:

Last refresh of the prices: Today at 10:28 AM -04.

Prices and availability are subject to change.

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Antofagasta to La Serena, CL: Trip Overview

Average Ticket PriceUS$41
Average Bus Trip Duration11h 30m
Number of daily buses25
Earliest bus departure12:15am
Distance705 km
Latest bus departure11:50pm

Antofagasta to La Serena Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Antofagasta to La Serena.

We make sure you can find a bus service from Antofagasta to La Serena from the most reliable bus companies operating this trip.

Discover how much the bus trip from Antofagasta to La Serena will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Antofagasta - La Serena, CL

  1. How far is Antofagasta from La Serena?

    It's about 704 km (437 miles) from Antofagasta to La Serena.

  2. What are the departure and arrival locations for buses traveling from Antofagasta to La Serena?

    Buses departing from Av. Pedro Aguirre Cerda, 253 in Antofagasta will take you to Terminal de Buses La Serena in La Serena.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
07-23
US$26
07-24
US$26
Today
US$20
07-26
US$26
07-27
US$36
07-28
US$33
07-29
US$20
07-30
US$38
busbud logoThe cheapest trip from Antofagasta to La Serena, CL was searched and found on Jul 25, 2025 with a price of US$20

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Antofagasta to La Serena, CL, as early as possible.

You can expect to pay from US$20 to US$53 for a bus ticket from Antofagasta to La Serena, CL based on the last 2 days. You can expect to find the cheapest price for the trip at US$20 which is on 2025-07-29.

Usually Buses Andimar will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Antofagasta to La Serena but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Antofagasta to La Serena, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Antofagasta to La Serena will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from Antofagasta to La Serena, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to Antofagasta by bus?

Bus from Antofagasta to La Serena, CL

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

People from around the world trust Busbud

‌

Popular Buses Connecting Antofagasta

Buses Leaving from Antofagasta

Buses Going to Antofagasta

Popular Buses Connecting La Serena

Buses Leaving from La Serena

Buses Going to La Serena