Based on 71 reviews, the company was rated 4 stars on Busbud. Travellers were especially satisfied with the departure location and the cleanliness but often complained with the WiFi. Pluss Chile ticket prices on this trip start at US$12
Based on 10578 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. FlixBus ticket prices on this trip start at US$9
Based on 51 reviews, the company was rated 4.3 stars on Busbud. Travellers were especially satisfied with the ticket access and the seats but often complained with the WiFi. Buses Andimar ticket prices on this trip start at US$14
Andimar Santiago La Serena recent customer reviews
We actually rebooked to Flixbus. We felt very safe two drivers and supported by a third person. Very properly! Nice service!
Based on 119 reviews, the company was rated 3.8 stars on Busbud. Travellers were especially satisfied with the staff and the ticket access but often complained with the WiFi. Cikbus Elité ticket prices on this trip start at US$9
Cikbus Elité / Ciktur Santiago La Serena recent customer reviews
Timely service, arrived a little early at destination. Comfortable, but the seat my partner had would not stay upright, it would slowly recline.
4 out of 5 stars
Nigel P.
The best company I have ever seen. Really comfortable seats and pillows. I have problems with sleeping in buses but now I had decent rest. I recommend
Based on 48 reviews, the company was rated 3.8 stars on Busbud. Travellers were especially satisfied with the ticket access and the seats but often complained with the WiFi. Buses Romani ticket prices on this trip start at US$9
Based on 13 reviews, the company was rated 3.6 stars on Busbud. Travellers were especially satisfied with the seats and the temperature but often complained with the timeliness. Pullman San Andres ticket prices on this trip start at US$14
According to 12 reviews, Buses Paravias received a 2.6-star rating for this journey. Travellers were especially satisfied with the staff and the seats, but some complained about the temperature. Buses Paravias ticket prices on this trip start at US$12
Buses Paravias Santiago La Serena recent customer reviews
Bus showed up an hour late without functioning AC. An hour into the trip the bus broke down and we had to wait two hours for a replacement, we were a total of 4 hours late to our destination. Never again.
1 out of 5 stars
Marco André A.
my bus was canceled, there was no information about it, I did not get refund for the ticket
1 out of 5 stars
Stefano S.
The bus really smelt of toilet and the air conditioner was broken. There was a window that the staff were not happy for us to open.
Based on 12 reviews, Serena Mar was rated 4 stars for this trip. Serena Mar ticket prices on this trip start at US$14, with the trip lasting on average 376.
Serena Mar Santiago La Serena recent customer reviews
While we were riding, there were an odd series of noises, noises that I presume were the audio of a film, coming from the speakers above the seats. The noises were quite annoying and went on for some time before the attendant came to stop them.
3 out of 5 stars
Matthew O.
It was a bit dirty
2 out of 5 stars
Andre C.
Toilet didn't work fully, but was a comfortable ride. All in all good!
Buses Evans offers 1 daily departures, and you can find tickets starting at US$47. The quickest ride takes around 420. Buses Evans offers a cost-effective solution to get you where you need to be.
Based on 19 reviews, Condor Bus was rated 3.6 stars for this trip. Condor Bus ticket prices on this trip start at US$15, with the trip lasting on average 418.
Based on 3 reviews, the company was rated 4.3 stars on Busbud. Travellers were especially satisfied with the staff and the timeliness but often complained with the WiFi. Clikbus ticket prices on this trip start at US$16
Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Santiago to La Serena.
We make it our job to connect you with the most dependable bus companies that cover bus service from Santiago to La Serena.
Discover how much the bus trip from Santiago to La Serena will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.
Where are the popular stops in Santiago and La Serena?
Stops in Santiago
A - San Borja
San Francisco de Borja 199-225, Santiago, Estación Central, Región Metropolitana, ChileSan Borja
B - Terminal Sur
Santiago - Av Libertador Bernardo O'Higgins 3850, Santiago, Estación Central, Región Metropolitana, ChileTerminal Sur
C - Terminal Los Héroes
Tucapel Jiménez 21, 8340528 Santiago, Región Metropolitana, ChileTerminal Los Héroes
D - Terminal ETM
Pdte. Riesco 6391-6399, Las Condes, Región Metropolitana, ChileTerminal ETM
E - Santiago
Juan Esteban Montero 5688, Las Condes, Las Condes, Región Metropolitana, ChileSantiago
F - Pajaritos
Av. Gral. Oscar Bonilla 418, Lo Prado, Región Metropolitana, ChilePajaritos
Panamericana Norte 208, La Serena, Región de Coquimbo, ChileRotonda La Serena
Frequently asked questions on the trip Santiago, CL - La Serena, CL
How far is Santiago from La Serena?
The distance between Santiago and La Serena is approximately 398 km (247 miles).
What are the departure and arrival locations for buses traveling from Santiago to La Serena?
Buses departing from San Borja in Santiago will take you to Terminal de Buses La Serena in La Serena.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
09-18
US$13
09-19
US$14
Today
US$11
09-21
US$14
09-22
US$9
09-23
US$8
09-24
US$8
09-25
US$8
The cheapest trip from Santiago, CL to La Serena, CL was searched and found on Sep 23, 2025 with a price of US$8
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago, CL to La Serena, CL, as early as possible.
You can expect to pay from US$8 to US$78 for a bus ticket from Santiago, CL to La Serena, CL based on the last 2 days. You can expect to find the cheapest price for the trip at US$8 which is on 2025-09-23.
Usually Pluss Chile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
About Bus Travel
Bus Travel Tips
If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Santiago to La Serena but it'll also be endearing to native speakers who will surely appreciate your effort.
From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Santiago to La Serena.
Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Santiago to La Serena will emit less CO2 than a car or an airplane.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Santiago to La Serena.
Did you know?
The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.
The cheapest trip from Santiago, CL to La Serena, CL was searched and found on Sep 23, 2025 with a price of US$8
