Bus Tickets from Santiago, CL to La Serena, CL

Next departures

Next departures for Santiago to La Serena on September 14
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Flixbus Chile
Terminal San Borja
La Serena (Bus terminal La Serena)Cheapest
Flixbus Chile
Santiago (Los Libertadores)
La Serena (Bus terminal La Serena)Fastest
Cikbus Elité
Terminal de Buses San Borja - San Francisco de Borja
Terminal de Buses La SerenaNo tags
Buses Romani
Terminal de Buses San Borja - San Francisco de Borja
Terminal de Buses La SerenaNo tags
Paravias
San Borja
Terminal de Buses La SerenaNo tags

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Santiago, CL to La Serena, CL: Trip Overview

Average Ticket PriceUS$17
Average Bus Trip Duration6h 20m
Number of daily buses68
Earliest bus departure5:50am
Distance398 km
Latest bus departure11:59pm

Santiago to La Serena Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Santiago to La Serena.

We make it our job to connect you with the most dependable bus companies that cover bus service from Santiago to La Serena.

Discover how much the bus trip from Santiago to La Serena will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Santiago, CL - La Serena, CL

  1. How far is Santiago from La Serena?

    The distance between Santiago and La Serena is approximately 398 km (247 miles).

  2. What are the departure and arrival locations for buses traveling from Santiago to La Serena?

    Buses departing from San Borja in Santiago will take you to Terminal de Buses La Serena in La Serena.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09-11
US$9
09-12
US$20
Today
US$16
09-14
US$13
09-15
US$20
09-16
US$22
09-17
US$21
09-18
US$11
busbud logoThe cheapest trip from Santiago, CL to La Serena, CL was searched and found on Sep 11, 2025 with a price of US$9

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago, CL to La Serena, CL, as early as possible.

You can expect to pay from US$9 to US$45 for a bus ticket from Santiago, CL to La Serena, CL based on the last 2 days. You can expect to find the cheapest price for the trip at US$11 which is on 2025-09-18.

Usually Pluss Chile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Santiago to La Serena but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Santiago to La Serena.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Santiago to La Serena will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Santiago to La Serena.

Did you know?

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Santiago, CL by bus?

Bus from La Serena, CL to Santiago, CL

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