Find coaches from Santiago, CL to La Serena, CL

Today3 Aug
from US$9
Tomorrow4 Aug
from US$9
Tue5 Aug
from US$9
Wed6 Aug
from US$9
Thu7 Aug
from US$9
Fri8 Aug
from US$9
Sat9 Aug
from US$9
Sun10 Aug
from US$9

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 4 August at
    Departure city: Santiago
    Departure location: Terminal de Buses San Borja - San Francisco de Borja
    Arrival time: 5 August at
    Destination city: La Serena
    Destination location: Terminal de Buses La Serena
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 4 August at
    Departure city: Santiago
    Departure location: San Borja
    Arrival time: 5 August at
    Destination city: La Serena
    Destination location: Terminal de Buses La Serena
    Operated by: Serena MarSerena Mar
    Vehicle: BusDuration:
  • Departure time: 4 August at
    Departure city: Santiago
    Departure location: Las Condes
    Arrival time: 5 August at
    Destination city: La Serena
    Destination location: Terminal de Buses La Serena
    Operated by: Buses RomaniBuses Romani
    Vehicle: BusDuration:
  • Departure time: 4 August at
    Departure city: Santiago
    Departure location: San Borja
    Arrival time: 4 August at
    Destination city: La Serena
    Destination location: Terminal de Buses La Serena
    Operated by: ParaviasParavias
    Vehicle: BusDuration:
  • Departure time: 4 August at
    Departure city: Santiago
    Departure location: Terminal de Buses San Borja - San Francisco de Borja
    Arrival time: 4 August at
    Destination city: La Serena
    Destination location: Terminal de Buses La Serena
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:

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Bus Santiago, CL to La Serena, CL: Trip Overview

Average ticket priceUS$15
Average bus trip duration6h 25m
Number of daily buses67
Earliest bus departure05:50
Distance247 miles
Latest bus departure23:59

Santiago to La Serena Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Santiago to La Serena.

We make it our job to connect you with the most dependable bus companies that cover bus service from Santiago to La Serena.

Discover how much the bus trip from Santiago to La Serena will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Santiago, CL - La Serena, CL

  1. What's the distance between Santiago and La Serena by coach?

    The journey from Santiago to La Serena by coach covers an approximate distance of 247 miles (398 km).

  2. How can I get from Santiago to La Serena without driving?

    You can reach La Serena from Santiago by coach, as there are regular services between the two locations. Depending on your preferences, another alternative is to explore ridesharing trips.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
01/08
US$10
02/08
US$10
Today
US$8
04/08
US$8
05/08
US$8
06/08
US$8
07/08
US$8
08/08
US$8
busbud logoThe cheapest trip from Santiago, CL to La Serena, CL was searched and found on 5 Aug 2025 with a price of US$8

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago, CL to La Serena, CL as early as possible.

You can expect to pay from US$8 to US$27 for a bus ticket from Santiago, CL to La Serena, CL based on the last 2 days. You can expect to find the cheapest price for the trip at US$8, which is on 2025-08-05.

Usually PlussChile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Santiago to La Serena but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Santiago to La Serena.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Santiago to La Serena will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Santiago to La Serena.

Did you know?

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Santiago, CL by bus?

Bus from Santiago, CL to La Serena, CL

Why choose Busbud?

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