Bus Tickets from Santiago, CL to Antofagasta

Next departures

Next departures for Santiago to Antofagasta on September 19
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Andimar
Terminal San Borja
Terminal de Buses Cardenal Carlos Oviedo Cavada)Cheapest
Pluss Chile
San Borja
Terminal AntofagastaFastest
Cikbus Elité
Terminal de Buses San Borja - San Francisco de Borja
Terminal AntofagastaNo tags
Pluss Chile
San Borja
Terminal AntofagastaNo tags
Pullman San Andrés
San Borja
Terminal Carlos Oviedo CavadaNo tags

Accepted payments

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  • China Union Pay
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  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Santiago, CL to Antofagasta: Trip Overview

Average ticket price$47
Average bus trip duration18h 40m
Number of daily buses36
Earliest bus departure6:50am
Distance679 miles (1094 km)
Latest bus departure11:59pm

Santiago to Antofagasta Bus

With Busbud, comparing and booking tickets for a bus from Santiago to Antofagasta is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Santiago to Antofagasta from the most reliable bus companies operating this trip.

Discover how much the bus trip from Santiago to Antofagasta will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip Santiago, CL - Antofagasta

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09/16
$44
09/17
$54
Today
$32
09/19
$34
09/20
$54
09/21
$35
09/22
$32
09/23
$32
busbud logoThe cheapest trip from Santiago, CL to Antofagasta was searched and found on Sep 18, 2025 with a price of $32

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago, CL to Antofagasta, as early as possible.

You can expect to pay from $32 to $74 for a bus ticket from Santiago, CL to Antofagasta based on the last 2 days. You can expect to find the cheapest price for the trip at $32 which is on 2025-09-22.

Usually Pluss Chile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Santiago to Antofagasta.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Santiago to Antofagasta, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Santiago to Antofagasta will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Santiago to Antofagasta.

Did you know?

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Santiago, CL by bus?

Bus from Antofagasta to Santiago, CL

Why choose Busbud?

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