Bus Tickets from San Luis Obispo to San Diego, CA, US

Next departures

Next departures for San Luis Obispo to San Diego on September 3
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
San Luis Obispo
Greyhound Bus StopCheapest
FlixBus
San Luis Obispo
UCSD Health La Jolla StationFastest
FlixBus
San Luis Obispo
UCSD Health La Jolla StationNo tags
Amtrak
Cal Poly Vista Grande Dining Complex
Santa Fe DepotNo tags
FlixBus
San Luis Obispo
Downtown SD (Seaport)No tags

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from San Luis Obispo to San Diego.

Bus
Average Price$34 - $92Average Duration10h 10m
11kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average Price$65 - $65Average Duration8h 52m
39kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from San Luis Obispo to San Diego

Among the sustainable travel choices, the train stands out as the good way to reach San Diego. The journey takes about 8 hours 52 minutes and with fares starting at just $65, it presents an excellent value for a comfortable ride.

1train per day
8h 52mAverage Duration
$65Cheapest ticket
39kgCO₂ emissions

Bus San Luis Obispo to San Diego, CA, US: Trip Overview

Average ticket price$76
Average bus trip duration10h 10m
Number of daily buses4
Earliest bus departure12:55pm
Distance266 miles (429 km)
Latest bus departure7:25pm

San Luis Obispo to San Diego Bus

With Busbud, comparing and booking tickets for a bus from San Luis Obispo to San Diego is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from San Luis Obispo to San Diego.

Whether it is cheap bus tickets or more luxurious buses going to San Diego from San Luis Obispo, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip San Luis Obispo - San Diego, CA, US

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
08/31
$68
09/01
$68
Today
$45
09/03
$42
09/04
$31
09/05
$68
09/06
$68
09/07
$68
busbud logoThe cheapest trip from San Luis Obispo to San Diego, CA, US was searched and found on Sep 4, 2025 with a price of $31

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Luis Obispo to San Diego, CA, US, as early as possible.

You can expect to pay from $31 to $130 for a bus ticket from San Luis Obispo to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $31 which is on 2025-09-04.

Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from San Luis Obispo to San Diego.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from San Luis Obispo to San Diego.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from San Luis Obispo to San Diego.

Tune out to the fine sounds of your best music playlist on your bus trip from San Luis Obispo to San Diego while indulging in miles on end of beautiful scenic views.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to San Luis Obispo by bus?

Bus from San Diego, CA, US to San Luis Obispo

You can also go to San Diego, CA, US by train

Train from San Luis Obispo to San Diego, CA, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

People from around the world trust Busbud

‌

Popular Buses Connecting San Luis Obispo

Buses Leaving from San Luis Obispo

Buses Going to San Luis Obispo

Popular Buses Connecting San Diego

Buses Leaving from San Diego

Buses Going to San Diego